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Sandbox c6

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<applet load='1o86' size='300' frame='true' align='right' caption='Insert caption here' />
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<Structure load='1ACJ' size='400' frame='true' align='right' caption='mi estructura favorita' />1ACJ shows the crystal structure of ''Torpedo californica'' acetylcholinesterase (TcAChE) complexed with '''tacrine'''.<ref>PMID 654</ref>
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Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
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It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
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Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330
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<scene name='Sandbox_c6/Tacrine1/1'> (W84 and F330)</scene>
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<ref>PMID:8415649</ref>
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Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
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<references/>

Current revision

mi estructura favorita

Drag the structure with the mouse to rotate
1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.[1]

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330

[2]

Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649

  1. ↑ Acar JF, Guibert J. [Relationship between serum antibiotic concentration and inhibiting potency of the serum. Application to ampicillin and amoxicillin]. Nouv Presse Med. 1975 Oct 15;4(34):2441-4. PMID:654
  2. ↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
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