2jc2
From Proteopedia
(New page: 200px<br /> <applet load="2jc2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jc2, resolution 2.50Å" /> '''THE CRYSTAL STRUCTU...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2JC2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JC2 OCA]]. | + | 2JC2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JC2 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: ryanodine receptor interacting protein]] | [[Category: ryanodine receptor interacting protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:13:31 2007'' |
Revision as of 09:08, 30 October 2007
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THE CRYSTAL STRUCTURE OF THE NATURAL F112L HUMAN SORCIN MUTANT
Overview
The penta-EF hand protein sorcin participates in the modulation of, Ca(2+)-induced calcium-release in the heart through the interaction with, several Ca(2+) channels such as the ryanodine receptor. The modulating, activity is impaired in the recently described natural F112L mutant. The, F112 residue is located at the end of the D helix next to Asp113, one of, the calcium ligands in the EF3 hand endowed with the highest affinity for, the metal. The F112L-sorcin X-ray crystal structure at 2.5 A resolution, displays marked alterations in the EF3 hand, where the hydrogen bonding, network established by Phe112 is disrupted, and in the EF1 region, which, is tilted in both monomers that give rise to the dimer, the stable form of, the molecule. In turn, the observed tilt is indicative of an ... [(full description)]
About this Structure
2JC2 is a [Single protein] structure of sequence from [Homo sapiens] with SO4 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor., Franceschini S, Ilari A, Verzili D, Zamparelli C, Antaramian A, Rueda A, Valdivia HH, Chiancone E, Colotti G, FASEB J. 2007 Aug 15;. PMID:17699613
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