This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2jc3
From Proteopedia
(New page: 200px<br /> <applet load="2jc3" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jc3, resolution 2.30Å" /> '''STRUCTURE OF O-ACET...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2JC3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]] with PLP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JC3 OCA]]. | + | 2JC3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]] with PLP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JC3 OCA]]. |
==Reference== | ==Reference== | ||
| Line 30: | Line 30: | ||
[[Category: vitamin b6 dependent enzyme]] | [[Category: vitamin b6 dependent enzyme]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:14:03 2007'' |
Revision as of 09:09, 30 October 2007
|
STRUCTURE OF O-ACETYLSERINE SULFHYDRYLASE B FROM SALMONELLA TYPHIMURIUM
Overview
O-Acetylserine sulfhydrylase is a pyridoxal 5'-phosphate-dependent enzyme, that catalyzes the final step in the cysteine biosynthetic pathway in, enteric bacteria and plants, the replacement of the beta-acetoxy group of, O-acetyl-l-serine by a thiol to give l-cysteine. Two isozymes are found in, Salmonella typhimurium, with the A-isozyme expressed under aerobic and the, B-isozyme expressed under anaerobic conditions. The structure of, O-acetylserine sulfhydrylase B has been solved to 2.3 A and exhibits, overall a fold very similar to that of the A-isozyme. The main difference, between the two isozymes is the more hydrophilic active site of the, B-isozyme with two ionizable residues, C280 and D281, replacing the, neutral residues S300 and P299, respectively, in the A-isozyme. D281 is, ... [(full description)]
About this Structure
2JC3 is a [Single protein] structure of sequence from [Salmonella typhimurium] with PLP as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure, Mechanism, and Conformational Dynamics of O-Acetylserine Sulfhydrylase from Salmonella typhimurium: Comparison of A and B Isozymes., Chattopadhyay A, Meier M, Ivaninskii S, Burkhard P, Speroni F, Campanini B, Bettati S, Mozzarelli A, Rabeh WM, Li L, Cook PF, Biochemistry. 2007 Jul 17;46(28):8315-30. Epub 2007 Jun 21. PMID:17583914
Page seeded by OCA on Tue Oct 30 11:14:03 2007
Categories: Salmonella typhimurium | Single protein | Burkhard, P. | Chattopadhyay, A. | Cook, P.F. | Ivaninskii, S. | Meier, M. | Mozzarelli, A. | Rabeh, W.M. | Speroni, F. | PLP | Amino-acid biosynthesis | Cysteine biosynthesis | Pyridoxal phosphate | Sulfhydrylase | Transferase | Vitamin b6 dependent enzyme
