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Fibronectin

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(New page: Crystal Structure of Fibronectin 4-5FnI fragment 1fbr {{STRUCTURE_1fbr| PDB=1fbr | SIZE=300| SCENE= |right|CAPTION=Fibronectin 4-5FnI fragment [[1...)
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[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]]
[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]]
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{{STRUCTURE_1fbr| PDB=1fbr | SIZE=300| SCENE= |right|CAPTION=Fibronectin 4-5FnI fragment [[1fbr]] }}
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{{STRUCTURE_1fbr| PDB=1fbr | SIZE=300| SCENE=Fibronectin/Cv/1 |right|CAPTION=Fibronectin 4-5FnI fragment [[1fbr]] }}
[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]).
[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]).
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=== Fn module FnI ===
=== Fn module FnI ===
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[[3m7p]] – hFn GBD – human
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[[3m7p]] – hFn GBD – human<br />
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1e8b, 1e88, 1qo6 - hFn GBD – NMR
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[[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br />
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3gxe, 3ejh – hFn 8-9FnI+collagen alpha-1
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[[3gxe]], [[3ejh]] – hFn 8-9FnI+collagen alpha-1<br />
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1fbr - hFn 4-5FnI
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[[1fbr]] - hFn 4-5FnI<br />
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2rky, 2rl0 – hFn 4-5FnI+Fn binding peptide
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[[2rky]], [[2rl0]] – hFn 4-5FnI+Fn binding peptide<br />
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2rkz, 3cal - hFn 2-3FnI+Fn binding peptide
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[[2rkz]], [[3cal]] - hFn 2-3FnI+Fn binding peptide<br />
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2cg6, 2cg7 - hFn 2-3FnI
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[[2cg6]], [[2cg7]] - hFn 2-3FnI<br />
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2cku - hFn 2-3FnI – NMR
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[[2cku]] - hFn 2-3FnI – NMR<br />
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1o9a - hFn 1-2FnI+B3 from FNBB – NMR
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[[1o9a]] - hFn 1-2FnI+B3 from FNBB – NMR<br />
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2ec3 – hFn 11FnI – NMR
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[[2ec3]] – hFn 11FnI – NMR<br />
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1qgb – hFn FnI N-terminal - NMR
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[[1qgb]] – hFn FnI N-terminal - NMR<br />
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2ck2 – hFn (mutant) core swapped
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[[2ck2]] – hFn (mutant) core swapped<br />
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1j8k – hFn extra domain 2 – NMR
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[[1j8k]] – hFn extra domain 2 – NMR<br />
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1fnh – hFn heparin and integrin binding domains
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[[1fnh]] – hFn heparin and integrin binding domains
=== Fn module FnII ===
=== Fn module FnII ===
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2fn2 – hFn 2FnII – NMR
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[[2fn2]] – hFn 2FnII – NMR
=== Fn module FnIII ===
=== Fn module FnIII ===
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2h41, 2h45 – hFn 2FnIII – NMR
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[[2h41]], [[2h45]] – hFn 2FnIII – NMR<br />
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1oww - hFn 1FnIII – NMR
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[[1oww]] - hFn 1FnIII – NMR<br />
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2ha1 - hFn 1-2FnIII – NMR
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[[2ha1]] - hFn 1-2FnIII – NMR<br />
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2crm - hFn 4FnIII – NMR
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[[2crm]] - hFn 4FnIII – NMR<br />
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2crz - hFn 5FnIII – NMR
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[[2crz]] - hFn 5FnIII – NMR<br />
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1fna, 1ttf, 1ttg – hFn 10FnIII
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[[1fna]], [[1ttf]], [[1ttg]] – hFn 10FnIII<br />
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1fnf – hFn 7-10FnIII
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[[1fnf]] – hFn 7-10FnIII<br />
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2fnb – hFn FnIII ed-b domain – NMR
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[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
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1mfn, 2mfn – Fn 9-10FnIII – mouse - NMR
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[[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR

Revision as of 08:53, 15 December 2010

Image:1fbr.png
Crystal Structure of Fibronectin 4-5FnI fragment 1fbr

Template:STRUCTURE 1fbr

Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, i.e. the crystal structure of human Fibronectin 4-5FnI fragment (1fbr).

Contents

3D Structures of Fibronectin

Fn module FnI

3m7p – hFn GBD – human
1e8b, 1e88, 1qo6 - hFn GBD – NMR
3gxe, 3ejh – hFn 8-9FnI+collagen alpha-1
1fbr - hFn 4-5FnI
2rky, 2rl0 – hFn 4-5FnI+Fn binding peptide
2rkz, 3cal - hFn 2-3FnI+Fn binding peptide
2cg6, 2cg7 - hFn 2-3FnI
2cku - hFn 2-3FnI – NMR
1o9a - hFn 1-2FnI+B3 from FNBB – NMR
2ec3 – hFn 11FnI – NMR
1qgb – hFn FnI N-terminal - NMR
2ck2 – hFn (mutant) core swapped
1j8k – hFn extra domain 2 – NMR
1fnh – hFn heparin and integrin binding domains


Fn module FnII

2fn2 – hFn 2FnII – NMR


Fn module FnIII

2h41, 2h45 – hFn 2FnIII – NMR
1oww - hFn 1FnIII – NMR
2ha1 - hFn 1-2FnIII – NMR
2crm - hFn 4FnIII – NMR
2crz - hFn 5FnIII – NMR
1fna, 1ttf, 1ttg – hFn 10FnIII
1fnf – hFn 7-10FnIII
2fnb – hFn FnIII ed-b domain – NMR
1mfn, 2mfn – Fn 9-10FnIII – mouse - NMR

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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