Catenin

From Proteopedia

Revision as of 08:31, 20 December 2010

Template:STRUCTURE 2z6g

Catenins (CTN) are proteins which make complexes with cadherin. α-CTN links cadherin (CDH) and α-actinin, it is encoded by 3 genes: α-E-CTN (epithelial), α-T-CTN (membrane bound), and α-N-CTN (neuronal). β-CTN is a subunit of the cadherin complex. It contains armadillo repeats which are a pair of helices forming hairpin structure. γ-CTN (or plakoglobin) is a component of desmosomes and contains armadillo repeats. δ-CTN is expressed in the brain and contains 10 armadillo repeats. p120 CTN is another member of the CTN family. The images at the left and at the right correspond to one representative Catenin, i.e. the crystal structure of full-length zebrafish β-catenin (2z6g).

3D Structures of Catenin

P120 CTN

3l6x, 3l6y – p120 CTN (mutant) +E-CDH – human

α-CTN

1l7c – mα-CTN C-terminal - mouse
1h6g - hα-CTN M domain
1dov - mα-CTN dimerization domain
1dow - mα-CTN dimerization domain+ mβ-CTN chimera

β-CTN

3diw – mβ-CTN C-terminal+Tax interaction protein 1
2z6g - β-CTN – zebrafish
2z6h - hβ-CTN C-terminal
2gl7 - hβ-CTN (mutant)+TCF-4+B-cell lymphoma protein
2g57 - β-CTN fragment – NMR
3bct, 2bct - mβ-CTN armadillo repeats
1v18 - mβ-CTN armadillo repeats+apc protein
1t08 - hβ-CTN armadillo repeats+apc protein+ hβ-CTN interacting protein
1th1 - hβ-CTN armadillo repeats+apc protein
1qz7 - hβ-CTN armadillo repeats+axis inhibition protein
1g3j - hβ-CTN armadillo repeats+TCF3-CBD
1p22 - hβ-CTN +skp1+trcp1
1luj - hβ-CTN C-terminal+ hβ-CTN interacting protein
1jdh, 1jpw - hβ-CTN C-terminal+HTCF-4
1m1e - mβ-CTN armadillo repeats + mβ-CTN interacting protein
1jpp - mβ-CTN armadillo repeats+apc protein
1i7x, 1i7w - mβ-CTN armadillo repeats+E-CDH
3ouw, 3oux - mβ-CTN+lymphoid enhancer-binding factor 1

γ-CTN

3ifq – hγ-CTN+E-CDH EC1+EC2+EC3