1olm
From Proteopedia
(New page: 200px<br /> <applet load="1olm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1olm, resolution 1.95Å" /> '''SUPERNATANT PROTEIN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OLM is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with VTQ as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OLM OCA]]. | + | 1OLM is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with VTQ as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OLM OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:18:19 2007'' |
Revision as of 09:13, 30 October 2007
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SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED VITAMIN E AND CHOLESTEROL BIOSYNTHESIS
Overview
The vast majority of monomeric lipid transport in nature is performed by, lipid-specific protein carriers. This class of proteins can enclose, cognate lipid molecules in a hydrophobic cavity and transport them across, the aqueous environment. Supernatant protein factor (SPF) is an enigmatic, representative of monomeric lipid transporters belonging to the SEC14, family. SPF stimulates squalene epoxidation, a downstream step of the, cholesterol biosynthetic pathway, by an unknown mechanism. Here, we, present the three-dimensional crystal structure of human SPF in complex, with RRR-alpha-tocopherylquinone, the major physiological oxidation, product of RRR-alpha-tocopherol, at a resolution of 1.95A. The structure, of the complex reveals how SPF sequesters RRR-alpha-tocopherylquinone, ... [(full description)]
About this Structure
1OLM is a [Protein complex] structure of sequences from [Homo sapiens] with VTQ as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis., Stocker A, Baumann U, J Mol Biol. 2003 Sep 26;332(4):759-65. PMID:12972248
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