This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2ebo
From Proteopedia
(New page: 200px<br /> <applet load="2ebo" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ebo, resolution 1.90Å" /> '''CORE STRUCTURE OF G...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2EBO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 2EBO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Ebola_virus_sp. Ebola virus sp.]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: CL. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2EBO OCA]]. |
==Reference== | ==Reference== | ||
Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution., Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS, Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10077567 10077567] | Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution., Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS, Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10077567 10077567] | ||
| - | [[Category: Ebola virus]] | + | [[Category: Ebola virus sp.]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kim, P.S.]] | [[Category: Kim, P.S.]] | ||
| Line 27: | Line 27: | ||
[[Category: gp2]] | [[Category: gp2]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:18:57 2007'' |
Revision as of 09:14, 30 October 2007
|
CORE STRUCTURE OF GP2 FROM EBOLA VIRUS
Overview
Ebola virions contain a surface transmembrane glycoprotein (GP) that is, responsible for binding to target cells and subsequent fusion of the viral, and host-cell membranes. GP is expressed as a single-chain precursor that, is posttranslationally processed into the disulfide-linked fragments GP1, and GP2. The GP2 subunit is thought to mediate membrane fusion. A soluble, fragment of the GP2 ectodomain, lacking the fusion-peptide region and the, transmembrane helix, folds into a stable, highly helical structure in, aqueous solution. Limited proteolysis studies identify a stable core of, the GP2 ectodomain. This 74-residue core, denoted Ebo-74, was, crystallized, and its x-ray structure was determined at 1.9-A resolution., Ebo-74 forms a trimer in which a long, central three-stranded coiled ... [(full description)]
About this Structure
2EBO is a [Single protein] structure of sequence from [Ebola virus sp.] with CL as [ligand]. Structure known Active Site: CL. Full crystallographic information is available from [OCA].
Reference
Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution., Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS, Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:10077567
Page seeded by OCA on Tue Oct 30 11:18:57 2007
