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1xkk

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==About this Structure==
==About this Structure==
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1XKK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKK OCA].
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[[1xkk]] is a 1 chain structure of [[Epidermal Growth Factor Receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The June 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Epidermal Growth Factor Receptor'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_6 10.2210/rcsb_pdb/mom_2010_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKK OCA].
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==See Also==
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*[[Epidermal Growth Factor Receptor]]
==Reference==
==Reference==
<ref group="xtra">PMID:15374980</ref><references group="xtra"/>
<ref group="xtra">PMID:15374980</ref><references group="xtra"/>
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[[Category: Epidermal Growth Factor Receptor]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: RCSB PDB Molecule of the Month]]
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Alligood, K J.]]
[[Category: Alligood, K J.]]
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[[Category: Epidermal growth factor receptor]]
[[Category: Epidermal growth factor receptor]]
[[Category: Kinase]]
[[Category: Kinase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:31:01 2009''
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Revision as of 09:34, 26 December 2010

Image:1xkk.png

Template:STRUCTURE 1xkk

Contents

EGFR kinase domain complexed with a quinazoline inhibitor- GW572016

Template:ABSTRACT PUBMED 15374980

About this Structure

1xkk is a 1 chain structure of Epidermal Growth Factor Receptor with sequence from Homo sapiens. The June 2010 RCSB PDB Molecule of the Month feature on Epidermal Growth Factor Receptor by David Goodsell is 10.2210/rcsb_pdb/mom_2010_6. Full crystallographic information is available from OCA.

See Also

Reference

  • Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Dickerson SH, Ellis B, Pennisi C, Horne E, Lackey K, Alligood KJ, Rusnak DW, Gilmer TM, Shewchuk L. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004 Sep 15;64(18):6652-9. PMID:15374980 doi:10.1158/0008-5472.CAN-04-1168

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