2es6
From Proteopedia
(New page: 200px<br /><applet load="2es6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2es6" /> '''Structure of the SAM domain of Vts1p'''<br /...) |
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| - | [[Image:2es6.gif|left|200px]]<br /><applet load="2es6" size=" | + | [[Image:2es6.gif|left|200px]]<br /><applet load="2es6" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''Structure of the SAM domain of Vts1p'''<br /> | '''Structure of the SAM domain of Vts1p'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2ES6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http:// | + | 2ES6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sam domain]] | [[Category: sam domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:31:25 2008'' |
Revision as of 10:31, 23 January 2008
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Structure of the SAM domain of Vts1p
Overview
Although the abundant sterile alpha motif (SAM) domain was originally, classified as a protein-protein interaction domain, it has recently been, shown that certain SAM domains have the ability to bind RNA, defining a, new type of post-transcriptional gene regulator. To further understand the, function of SAM-RNA recognition, we determined the solution structures of, the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the, Smaug response element (SRE) stem-loop RNA as a complex and in isolation., The structures show that Vts1p-SAM recognizes predominantly the shape of, the SRE rather than its sequence, with the exception of a G located at the, tip of the pentaloop. Using microarray gene profiling, we identified, several genes in S. cerevisiae that seem to be regulated by Vts1p and, contain one or more copies of the SRE.
About this Structure
2ES6 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Shape-specific recognition in the structure of the Vts1p SAM domain with RNA., Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH, Nat Struct Mol Biol. 2006 Feb;13(2):160-7. Epub 2006 Jan 22. PMID:16429156
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