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1z77
From Proteopedia
(New page: 200px<br /><applet load="1z77" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z77, resolution 2.00Å" /> '''Crystal structure of...) |
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| - | [[Image:1z77.gif|left|200px]]<br /><applet load="1z77" size=" | + | [[Image:1z77.gif|left|200px]]<br /><applet load="1z77" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1z77, resolution 2.00Å" /> | caption="1z77, resolution 2.00Å" /> | ||
'''Crystal structure of transcriptional regulator protein from Thermotoga maritima.'''<br /> | '''Crystal structure of transcriptional regulator protein from Thermotoga maritima.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1Z77 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with EDO as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1Z77 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z77 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transcriptional regulator]] | [[Category: transcriptional regulator]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:47:51 2008'' |
Revision as of 10:47, 23 January 2008
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Crystal structure of transcriptional regulator protein from Thermotoga maritima.
Overview
The crystal structure of a putative transcriptional regulator protein, TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was, determined by an unusual multi-wavelength anomalous dispersion method at, 2.0 A resolution, in which data from two different crystals and two, different beamlines were used. The protein belongs to the tetracycline, repressor TetR superfamily. The three-dimensional structure of TM1030 is, similar to the structures of proteins that function as multidrug-binding, transcriptional repressors, and contains a large solvent-exposed pocket, similar to the drug-binding pockets present in those repressors. The, asymmetric unit in the crystal structure contains a single protein chain, and the twofold symmetry of the dimer is adopted by the crystal symmetry., The structure described in this paper is an apo- form of TM1030. Although, it is known that the protein is significantly overexpressed during heat, shock, its detailed function cannot be yet explained.
About this Structure
1Z77 is a Single protein structure of sequence from Thermotoga maritima with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment., Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W, J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:17588774
Page seeded by OCA on Wed Jan 23 12:47:51 2008
Categories: Single protein | Thermotoga maritima | Chruszcz, M. | Cymborowski, M. | Koclega, K.D. | Kudritska, M. | MCSG, Midwest.Center.for.Structural.Genomics. | Minor, W. | Zimmerman, M.D. | EDO | Mcsg | Midwest center for structural genomics | Protein structure initiative | Psi | Structural genomics | Tetr family | Transcriptional regulator
