This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1z6j
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:1z6j.png|left|200px]] | [[Image:1z6j.png|left|200px]] | ||
| Line 18: | Line 17: | ||
--> | --> | ||
{{ABSTRACT_PUBMED_15913999}} | {{ABSTRACT_PUBMED_15913999}} | ||
| - | |||
| - | ==Disease== | ||
| - | Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1z6j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6J OCA]. | |
==Reference== | ==Reference== | ||
| Line 44: | Line 40: | ||
[[Category: Enzyme inhibitor complex]] | [[Category: Enzyme inhibitor complex]] | ||
[[Category: Gla]] | [[Category: Gla]] | ||
| + | [[Category: Hydrolase]] | ||
[[Category: Pyrazinone]] | [[Category: Pyrazinone]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Thrombosis]] | [[Category: Thrombosis]] | ||
[[Category: Tissue factor]] | [[Category: Tissue factor]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:02:57 2009'' | ||
Revision as of 17:47, 29 December 2010
Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor
Template:ABSTRACT PUBMED 15913999
About this Structure
1z6j is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Schweitzer BA, Neumann WL, Rahman HK, Kusturin CL, Sample KR, Poda GI, Kurumbail RG, Stevens AM, Stegeman RA, Stallings WC, South MS. Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3006-11. PMID:15913999 doi:10.1016/j.bmcl.2005.04.037
- South MS, Case BL, Wood RS, Jones DE, Hayes MJ, Girard TJ, Lachance RM, Nicholson NS, Clare M, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ. Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2319-25. PMID:12824026
- Parlow JJ, Dice TA, Lachance RM, Girard TJ, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, South MS. Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors. J Med Chem. 2003 Sep 11;46(19):4043-9. PMID:12954057 doi:http://dx.doi.org/10.1021/jm030130t
Categories: Coagulation factor VIIa | Homo sapiens | Kurumbail, R G. | Kusturin, C L. | Neumann, W L. | Poda, G I. | Rahman, H K. | Sample, K R. | Schweitzer, B A. | Stallings, W C. | Stegeman, R A. | Stevens, A M. | Benzamidine | Blood coagulation | Cofactor | Enzyme inhibitor complex | Gla | Hydrolase | Pyrazinone | Serine protease | Thrombosis | Tissue factor
