Ubiquitin
From Proteopedia
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[[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]] – hUBB – NMR<br /> | [[2kn5]], [[2klg]], [[2jzz]], [[2pe9]], [[2pea]], [[1g6j]], [[1d3z]] – hUBB – NMR<br /> | ||
| - | [[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]] - hUBB<br /> | + | [[2ojr]], [[2nr2]], [[2fcq]], [[1ubi]], [[1ubq]], [[1xqq]] - hUBB<br /> |
[[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]] - hUBB (mutant)<br /> | [[2zcb]], [[2gbj]], [[2gbk]], [[2gbm]], [[2gbn]], [[2gbr]], [[2fcm]], [[2fcn]], [[2fcs]], [[1yiw]], [[1yj1]], [[1sif]], [[1ogw]] - hUBB (mutant)<br /> | ||
[[1c3t]], [[1ud7]] - hUBB (mutant) - NMR<br /> | [[1c3t]], [[1ud7]] - hUBB (mutant) - NMR<br /> | ||
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[[3n3k]], [[3ifw]], [[3kvf]], [[3kw5]], [[3irt]], [[3mtn]], [[3ihp]] – hUBB (mutant)+hUBB carboxyl-terminal esterase catalytic domain<br /> | [[3n3k]], [[3ifw]], [[3kvf]], [[3kw5]], [[3irt]], [[3mtn]], [[3ihp]] – hUBB (mutant)+hUBB carboxyl-terminal esterase catalytic domain<br /> | ||
[[3i3t]], [[2ibi]], [[2ayo]], [[1nbf]] - hUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br /> | [[3i3t]], [[2ibi]], [[2ayo]], [[1nbf]] - hUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br /> | ||
| - | [[2hd5]] - bUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br /> | ||
| - | [[3ldz]] – bUBB+signal transducing adapter molecule<br /> | ||
[[2khw]] – hUBB+immunoglobulin G-binding protein G<br /> | [[2khw]] – hUBB+immunoglobulin G-binding protein G<br /> | ||
| - | [[2kdi]] – yUBB/UIM fusion <br /> | ||
| - | [[1v80]], [[1v81]] – bUBB/L40 ribosomal protein fusion - NMR<br /> | ||
[[1yx5]], [[1yx6]] - hUBB+26S proteasome non-ATPase regulatory subunit – NMR<br /> | [[1yx5]], [[1yx6]] - hUBB+26S proteasome non-ATPase regulatory subunit – NMR<br /> | ||
[[2k6d]] – hUBB+SH3 domain-containing kinase-binding protein – NMR<br /> | [[2k6d]] – hUBB+SH3 domain-containing kinase-binding protein – NMR<br /> | ||
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[[2jy6]] – hUBB+hUbiquilin – NMR<br /> | [[2jy6]] – hUBB+hUbiquilin – NMR<br /> | ||
[[3by4]], [[3c0r]] – hUBB+yUBB thioesterase<br /> | [[3by4]], [[3c0r]] – hUBB+yUBB thioesterase<br /> | ||
| - | [[2jt4]] – yUBB fragment+cytoskeleton assembly control protein<br /> | ||
[[2hth]] – hUBB+vacuolar protein sorting protein<br /> | [[2hth]] – hUBB+vacuolar protein sorting protein<br /> | ||
| + | [[1s1q]] – hUBB+tumor susceptibility gene 101 protein<br /> | ||
| + | [[1q5w]] – hUBB+NPL4 zinc-fingers<br /> | ||
| + | [[2k8b]], [[2k8c]] – hUBB+phospholipase A2-activating protein fragment<br /> | ||
| + | [[2ktf]] – hUBB+hDNA polymerase IOTA<br /> | ||
| + | [[2l0f]] – hUBB (mutant)+hDNA polymerase IOTA<br /> | ||
| + | [[2kwu]], [[2kwv]] - hUBB+mDNA polymerase IOTA – mouse<br /> | ||
| + | [[2l0t]] – hUBB+signal transducing adapter molecule 2<br /> | ||
| + | [[3o65]] – hUBB+ataxin-3-like protein josephin domain<br /> | ||
| + | [[3oj3]] – hUBB+tumor necrosis factor -induced protein 3<br /> | ||
| + | [[1uzx]] – bUBB+VPS23 UEV<br /> | ||
| + | [[2hd5]] - bUBB+hUBB carboxyl-terminal hydrolase catalytic domain<br /> | ||
| + | [[3ldz]] – bUBB+signal transducing adapter molecule<br /> | ||
| + | [[1v80]], [[1v81]] – bUBB/L40 ribosomal protein fusion - NMR<br /> | ||
[[2dx5]], [[1p3q]] - bUBB+vacuolar protein sorting protein<br /> | [[2dx5]], [[1p3q]] - bUBB+vacuolar protein sorting protein<br /> | ||
| - | [[1q0w]] - yUBB+vacuolar protein sorting protein<br /> | ||
| - | [[2g3q]] – yUBB+EDE1 UBA<br /> | ||
[[2c7m]], [[2c7n]], [[2fid]], [[2fif]] – bUBB+RAB guanine nucleotide exchange factor<br /> | [[2c7m]], [[2c7n]], [[2fid]], [[2fif]] – bUBB+RAB guanine nucleotide exchange factor<br /> | ||
[[2d3g]] – bUBB+HRS-UIM<br /> | [[2d3g]] – bUBB+HRS-UIM<br /> | ||
[[1wrd]] – bUBB+TOM1 GAT domain<br /> | [[1wrd]] – bUBB+TOM1 GAT domain<br /> | ||
[[1wr6]], [[1yd8]] - bUBB+GGA3 GAT domain<br /> | [[1wr6]], [[1yd8]] - bUBB+GGA3 GAT domain<br /> | ||
| - | [[1wr1]] – yUBB+DSK2P UBA<br /> | ||
| - | [[1s1q]] – hUBB+tumor susceptibility gene 101 protein<br /> | ||
| - | [[1q5w]] – hUBB+NPL4 zinc-fingers<br /> | ||
[[1uzx]] – bUBB+VPS23 UEV<br /> | [[1uzx]] – bUBB+VPS23 UEV<br /> | ||
| + | [[2kdi]] – yUBB/UIM fusion <br /> | ||
| + | [[2jt4]] – yUBB fragment+cytoskeleton assembly control protein<br /> | ||
| + | [[1q0w]] - yUBB+vacuolar protein sorting protein<br /> | ||
| + | [[2g3q]] – yUBB+EDE1 UBA<br /> | ||
| + | [[1wr1]] – yUBB+DSK2P UBA<br /> | ||
[[1otr]] – yUBB+CUE2<br /> | [[1otr]] – yUBB+CUE2<br /> | ||
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[[3jsv]], [[2zvn]], [[2zvo]] – hDiUBB+NF-κ-b essential modulator<br /> | [[3jsv]], [[2zvn]], [[2zvo]] – hDiUBB+NF-κ-b essential modulator<br /> | ||
[[2kde]], [[2kdf]] – DiUBB+26S proteasome non-ATPase regulatory subunit – NMR<br /> | [[2kde]], [[2kdf]] – DiUBB+26S proteasome non-ATPase regulatory subunit – NMR<br /> | ||
| - | [[3a1q]] – mDiUBB+UBB interaction motif-containing protein | + | [[3a1q]] – mDiUBB+UBB interaction motif-containing protein <br /> |
[[3dvg]], [[3dvn]] – hDiUBB+IGG1 fab light&heavy chains<br /> | [[3dvg]], [[3dvn]] – hDiUBB+IGG1 fab light&heavy chains<br /> | ||
[[2znv]] – mDiUBB+hAMSH-like protease<br /> | [[2znv]] – mDiUBB+hAMSH-like protease<br /> | ||
Revision as of 11:39, 2 January 2011
Ubiquitin (UBB) is found in almost all cells. It binds to proteins tagging them for destruction in the proteasome. UBB is activated by the UBB-activating enzymes E1, E2 and E3. UBB+1 is a frameshifted mutant of UBB observed in several diseases. A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule. At least 4 UBB molecules are needed to tag a protein for the proteasome. The images at the left and at the right correspond to one representative Ubiquitin, i.e. the NMR structure of human Ubiquitin (1d3z).
Contents |
Additional Resources
See: Ubiquitin Structure & Function for additional information.
3D Structures of Ubiquitin
Ubiquitin
2kn5, 2klg, 2jzz, 2pe9, 2pea, 1g6j, 1d3z – hUBB – NMR
2ojr, 2nr2, 2fcq, 1ubi, 1ubq, 1xqq - hUBB
2zcb, 2gbj, 2gbk, 2gbm, 2gbn, 2gbr, 2fcm, 2fcn, 2fcs, 1yiw, 1yj1, 1sif, 1ogw - hUBB (mutant)
1c3t, 1ud7 - hUBB (mutant) - NMR
1gjz – hUBB N-terminal – NMR
1e0q - hUBB N-terminal (mutant) – NMR
2k39 – UBB – Xenopus laevis – NMR
2jwz, 1zw7 – yUBB (mutant) – yeast
1cmx – yUBB (modified)
2zcc – bUBB - bovine
Ubiquitin+UBB-activating enzymes
3cmm – yUBB+E1
3k9p, 3a33 – hUBB+E2
2gmi - hUBB+E2+MMS2
2kjh, 1zgu – hUBB (mutant)+E2
3jvz, 3jw0 – hUBB+E2+E3
Ubiquitin+1 mutant
2kx0 – hUBB+1 – human – NMR
3k9o – hUBB+1+E2
Ubiquitin dimer
2xk5, 3nob, 2xew, 3h7p, 3h7s, 2w9n, 2jf5 – hDiUBB
3m3j, 1aar – bDiUBB
2bgf – hDiUBB – chemical relaxation
Ubiquitin tetramer
3alb, 3hm3, 2o6v, 1f9j, 1tbe – tetra-hUBB
Ubiquitin bound to protein
3ofi – hUBB+insulin protease
3n3k, 3ifw, 3kvf, 3kw5, 3irt, 3mtn, 3ihp – hUBB (mutant)+hUBB carboxyl-terminal esterase catalytic domain
3i3t, 2ibi, 2ayo, 1nbf - hUBB+hUBB carboxyl-terminal hydrolase catalytic domain
2khw – hUBB+immunoglobulin G-binding protein G
1yx5, 1yx6 - hUBB+26S proteasome non-ATPase regulatory subunit – NMR
2k6d – hUBB+SH3 domain-containing kinase-binding protein – NMR
2z59 – hUBB+mProtein Adhesion-regulating molecule 1
2jy6 – hUBB+hUbiquilin – NMR
3by4, 3c0r – hUBB+yUBB thioesterase
2hth – hUBB+vacuolar protein sorting protein
1s1q – hUBB+tumor susceptibility gene 101 protein
1q5w – hUBB+NPL4 zinc-fingers
2k8b, 2k8c – hUBB+phospholipase A2-activating protein fragment
2ktf – hUBB+hDNA polymerase IOTA
2l0f – hUBB (mutant)+hDNA polymerase IOTA
2kwu, 2kwv - hUBB+mDNA polymerase IOTA – mouse
2l0t – hUBB+signal transducing adapter molecule 2
3o65 – hUBB+ataxin-3-like protein josephin domain
3oj3 – hUBB+tumor necrosis factor -induced protein 3
1uzx – bUBB+VPS23 UEV
2hd5 - bUBB+hUBB carboxyl-terminal hydrolase catalytic domain
3ldz – bUBB+signal transducing adapter molecule
1v80, 1v81 – bUBB/L40 ribosomal protein fusion - NMR
2dx5, 1p3q - bUBB+vacuolar protein sorting protein
2c7m, 2c7n, 2fid, 2fif – bUBB+RAB guanine nucleotide exchange factor
2d3g – bUBB+HRS-UIM
1wrd – bUBB+TOM1 GAT domain
1wr6, 1yd8 - bUBB+GGA3 GAT domain
1uzx – bUBB+VPS23 UEV
2kdi – yUBB/UIM fusion
2jt4 – yUBB fragment+cytoskeleton assembly control protein
1q0w - yUBB+vacuolar protein sorting protein
2g3q – yUBB+EDE1 UBA
1wr1 – yUBB+DSK2P UBA
1otr – yUBB+CUE2
Ubiquitin dimer bound to protein
3a9j, 3a9k, 2wwz, 2wx0, 2wx1 – hDiUBB+mitogen-activated protein kinase
3jsv, 2zvn, 2zvo – hDiUBB+NF-κ-b essential modulator
2kde, 2kdf – DiUBB+26S proteasome non-ATPase regulatory subunit – NMR
3a1q – mDiUBB+UBB interaction motif-containing protein
3dvg, 3dvn – hDiUBB+IGG1 fab light&heavy chains
2znv – mDiUBB+hAMSH-like protease
Ubiquitin + ions
3h1u – bUBB+Cd
3ehv, 3eec, 3efu – hUBB+ions
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, David Canner, Jaime Prilusky
