Dipeptidyl peptidase
From Proteopedia
(New page: Crystal Structure of Dipeptidyl peptidase (1jqp) {{STRUCTURE_1jqp| PDB=1jqp | SIZE=300| SCENE= |right|CAPTION=Dipeptidyl peptidase 1jqp}} [[D...) |
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[[Image:1jqp.png|left|200px|thumb|Crystal Structure of Dipeptidyl peptidase ([[1jqp]])]] | [[Image:1jqp.png|left|200px|thumb|Crystal Structure of Dipeptidyl peptidase ([[1jqp]])]] | ||
| - | {{STRUCTURE_1jqp| PDB=1jqp | SIZE=300| SCENE= |right|CAPTION=Dipeptidyl peptidase [[1jqp]]}} | + | {{STRUCTURE_1jqp| PDB=1jqp | SIZE=300| SCENE=Dipeptidyl_peptidase/Cv/1 |right|CAPTION=Dipeptidyl peptidase [[1jqp]]}} |
[[Dipeptidyl peptidase]] (DPP) is an enzyme which cleaves dipeptides from plolypeptides. DPP-IV (or CD26) cleaves proline dipeptides from the N-termini and is associated with immune regulation. DPP-III acts similarly to DPP-IV. DPP-I is involved in inflammatory diseases. DPP-II is a serine protease. The images at the left and at the right correspond to one representative DPP, ''i.e.'' the crystal structure of Dipeptidyl peptidase-I from rat ([[1jqp]], chain J). | [[Dipeptidyl peptidase]] (DPP) is an enzyme which cleaves dipeptides from plolypeptides. DPP-IV (or CD26) cleaves proline dipeptides from the N-termini and is associated with immune regulation. DPP-III acts similarly to DPP-IV. DPP-I is involved in inflammatory diseases. DPP-II is a serine protease. The images at the left and at the right correspond to one representative DPP, ''i.e.'' the crystal structure of Dipeptidyl peptidase-I from rat ([[1jqp]], chain J). | ||
Revision as of 11:17, 3 January 2011
Dipeptidyl peptidase (DPP) is an enzyme which cleaves dipeptides from plolypeptides. DPP-IV (or CD26) cleaves proline dipeptides from the N-termini and is associated with immune regulation. DPP-III acts similarly to DPP-IV. DPP-I is involved in inflammatory diseases. DPP-II is a serine protease. The images at the left and at the right correspond to one representative DPP, i.e. the crystal structure of Dipeptidyl peptidase-I from rat (1jqp, chain J).
3D Structures of Dipeptidyl peptidase
DPP-I
1jqp – rDPP-I – rat
DPP-II
3n0t – hDPP-II peptidase domain residues 28-492+inhibitor - human
3jyh – hDPP-II peptidase domain residues 28-492
DPP-III
3fvy – hDPP-III
3csk – DPP-III (mutant) – yeast
DPP-IV
2onc, 1tk3, 1r9m, 1j2e, 1nu6, 1pfq – hDPP-IV extracellular domain
1u8e – hDPP-IV extracellular domain (mutant)
3kwj, 3oc0, 3kwf – hDPP-IV extracellular domain +quinoline derivative
3g0b, 3g0d, 3g0g, 3nox, 3hab, 3hac, 3f8s, 3h0c, 3ccb, 3ccc, 2qjr, 2qky, 3d4l, 3jid, 3bjm, 2rip, 2ole, 2rgu, 2i78, 2oag, 2oqv, 2oqi, 2ogz, 2i03, 2g5p, 2g5t, 2g63, 2bub, 2ajl, 1wcy, 1rwq, 1tkr, 1n1m – hDPP-IV extracellular domain+inhibitor
1r9n, 2bgr, 1nu8 – hDPP-IV extracellular domain+polypeptide
1w1i – hDPP-IV extracellular domain+adenosine deaminase
2bgn – hDPP-IV extracellular domain+adenosine deaminase+polypeptide
3c43, 3c45, 2qoe, 2qt9, 2qtb, 2p8s, 2oph, 2fjp, 1x70 – hDPP-IV extracellular domain (mutant)+inhibitor
2gbc – rDPP-IV extracellular domain
2oae, 2i3z, 2gbf, 2gbg, 2gbi – rDPP-IV extracellular domain+inhibitor
2aj8, 2ajb, 2ajc, 2ajd, 2bua, 2buc – DPP-IV extracellular domain+inhibitor - pig
