This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Villin
From Proteopedia
| Line 21: | Line 21: | ||
[[3fg7]] – hVIL gelsolin domains 4-6<br /> | [[3fg7]] – hVIL gelsolin domains 4-6<br /> | ||
[[1unc]] – hVIL headpiece<br /> | [[1unc]] – hVIL headpiece<br /> | ||
| + | [[3iur]] - hVIL headpiece H2H3 helices+prolyl endopeptidase – ''Aeromonas punctata''<br /> | ||
[[2rjw]], [[2rjx]], [[2rjv]], [[2rjy]], [[1yu7]], [[1yu8]] – cVIL headpiece (mutant) – chicken<br /> | [[2rjw]], [[2rjx]], [[2rjv]], [[2rjy]], [[1yu7]], [[1yu8]] – cVIL headpiece (mutant) – chicken<br /> | ||
[[1yu5]], [[1qqv]] - cVIL headpiece<br /> | [[1yu5]], [[1qqv]] - cVIL headpiece<br /> | ||
Revision as of 15:03, 3 February 2011
Template:STRUCTURE 2k6n Villin (VIL) is an actin-binding protein. The images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n). It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. [1] Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons.
3D Structures of Villin
Supervillin
2k6m, 2k6n – hSVIL headpiece– human – NMR
Villin
3fg7 – hVIL gelsolin domains 4-6
1unc – hVIL headpiece
3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic
Advillin
1und – hAVIL headpiece
References
- ↑ Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, David Canner, Jaime Prilusky, Joel L. Sussman
