Journal:JMedChem:1
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='Estr1.pdb' size='500' side='right' scene='Journal:JMEDCHEM:1/Cv/ | + | <StructureSection load='Estr1.pdb' size='500' side='right' scene='Journal:JMEDCHEM:1/Cv/2' caption=''> |
=== Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of SERMs === | === Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of SERMs === | ||
<big>Min-Jun Li, Harry M Greenblatt, Orly Dym, Shira Albeck, Adi Pais, Chidambaram Gunanathan, David Milstein, Hadassa Degani, and Joel L. Sussman</big> | <big>Min-Jun Li, Harry M Greenblatt, Orly Dym, Shira Albeck, Adi Pais, Chidambaram Gunanathan, David Milstein, Hadassa Degani, and Joel L. Sussman</big> | ||
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<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
| - | Selective estrogen receptor modulators, such as estradiol 17-derived metal complexes, have been synthesized as targeted probes for the diagnosis and treatment of breast cancer. Here, we report the detailed 3D structure of estrogen receptor alpha ligand-binding domain (ER-LBD) bound with a novel estradiol-derived metal complex, estradiol-pyridinium tetra acetate europium (III) at 2.6 resolution. This structure provides important information pertinent to the design of novel functional ER targeted probes for clinical applications. | + | Selective <scene name='Journal:JMEDCHEM:1/Cv/3'>estrogen receptor</scene> modulators, such as estradiol 17-derived metal complexes, have been synthesized as targeted probes for the diagnosis and treatment of breast cancer. Here, we report the detailed 3D structure of estrogen receptor alpha ligand-binding domain (ER-LBD) bound with a novel estradiol-derived metal complex, estradiol-pyridinium tetra acetate europium (III) at 2.6 resolution. This structure provides important information pertinent to the design of novel functional ER targeted probes for clinical applications. |
</StructureSection> | </StructureSection> | ||
<references/> | <references/> | ||
__NOEDITSECTION__ | __NOEDITSECTION__ | ||
Revision as of 09:24, 17 February 2011
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