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3pp1

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Revision as of 05:41, 9 March 2011

Image:3pp1.png

Template:STRUCTURE 3pp1

Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP

Template:ABSTRACT PUBMED 21310613

About this Structure

3pp1 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Dong Q, Dougan DR, Gong X, Halkowycz P, Jin B, Kanouni T, O'Connell SM, Scorah N, Shi L, Wallace MB, Zhou F. Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1315-9. Epub 2011 Jan 22. PMID:21310613 doi:10.1016/j.bmcl.2011.01.071

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OCA

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