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1ump

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Image:1ump.png

Template:STRUCTURE 1ump

GEOMETRY OF TRITERPENE CONVERSION TO PENTACARBOCYCLIC HOPENE

Template:ABSTRACT PUBMED 15113001

About this Structure

1ump is a 3 chain structure with sequence from Alicyclobacillus acidocaldarius. The December 2007 RCSB PDB Molecule of the Month feature on Oxidosqualene Cyclase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2007_12. Full crystallographic information is available from OCA.

Reference

  • Reinert DJ, Balliano G, Schulz GE. Conversion of squalene to the pentacarbocyclic hopene. Chem Biol. 2004 Jan;11(1):121-6. PMID:15113001 doi:http://dx.doi.org/10.1016/j.chembiol.2003.12.013
  • Lenhart A, Weihofen WA, Pleschke AE, Schulz GE. Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071. Chem Biol. 2002 May;9(5):639-45. PMID:12031670
  • Wendt KU, Lenhart A, Schulz GE. The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution. J Mol Biol. 1999 Feb 12;286(1):175-87. PMID:9931258 doi:http://dx.doi.org/10.1006/jmbi.1998.2470
  • Wendt KU, Poralla K, Schulz GE. Structure and function of a squalene cyclase. Science. 1997 Sep 19;277(5333):1811-5. PMID:9295270
  • Wendt KU, Feil C, Lenhart A, Poralla K, Schulz GE. Crystallization and preliminary X-ray crystallographic analysis of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. Protein Sci. 1997 Mar;6(3):722-4. PMID:9070455 doi:10.1002/pro.5560060322

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OCA

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