1w3c
From Proteopedia
(New page: 200px<br /> <applet load="1w3c" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w3c, resolution 2.3Å" /> '''CRYSTAL STRUCTURE OF...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1W3C is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 1W3C is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Viruses Viruses]] with DN1 and DN2 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W3C OCA]]. |
==Reference== | ==Reference== | ||
The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease., Ontoria JM, Di Marco S, Conte I, Di Francesco ME, Gardelli C, Koch U, Matassa VG, Poma M, Steinkuhler C, Volpari C, Harper S, J Med Chem. 2004 Dec 16;47(26):6443-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15588076 15588076] | The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease., Ontoria JM, Di Marco S, Conte I, Di Francesco ME, Gardelli C, Koch U, Matassa VG, Poma M, Steinkuhler C, Volpari C, Harper S, J Med Chem. 2004 Dec 16;47(26):6443-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15588076 15588076] | ||
| - | [[Category: Hepatitis c virus (isolate 1)]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Viruses]] | ||
[[Category: Marco, S.Di.]] | [[Category: Marco, S.Di.]] | ||
[[Category: Volpari, C.]] | [[Category: Volpari, C.]] | ||
| Line 22: | Line 22: | ||
[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:41:29 2007'' |
Revision as of 09:36, 30 October 2007
|
CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS3 PROTEASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR
Overview
The design of a series of peptidomimetic inhibitors of the hepatitis C, virus NS3 protease is described. These inhibitors feature an, indoline-2-carboxamide as a novel heterocyclic replacement for the P3, amino acid residue and N-terminal capping group of tripeptide based, inhibitors. The crystal structure of the ternary NS3/NS4A/inhibitor, complex for the most active molecule in this series highlights its, suitability as an N-terminal capping group of a dipeptide inhibitor of the, NS3 protease.
About this Structure
1W3C is a [Single protein] structure of sequence from [Viruses] with DN1 and DN2 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease., Ontoria JM, Di Marco S, Conte I, Di Francesco ME, Gardelli C, Koch U, Matassa VG, Poma M, Steinkuhler C, Volpari C, Harper S, J Med Chem. 2004 Dec 16;47(26):6443-6. PMID:15588076
Page seeded by OCA on Tue Oct 30 11:41:29 2007
