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3b7s

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Image:3b7s.png

Template:STRUCTURE 3b7s

Contents

[E296Q]LTA4H in complex with RSR substrate

Template:ABSTRACT PUBMED 18804029

About this Structure

3b7s is a 2 chain structure of Leukotriene A4 Hydrolase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Tholander F, Muroya A, Roques BP, Fournie-Zaluski MC, Thunnissen MM, Haeggstrom JZ. Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design. Chem Biol. 2008 Sep 22;15(9):920-9. PMID:18804029 doi:10.1016/j.chembiol.2008.07.018
  • Tholander F, Haeggstrom JZ. Assay for rapid analysis of the tri-peptidase activity of LTA4 hydrolase. Proteins. 2007 Jun 1;67(4):1113-8. PMID:17357161 doi:10.1002/prot.21329
  • Rudberg PC, Tholander F, Andberg M, Thunnissen MM, Haeggstrom JZ. Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates. J Biol Chem. 2004 Jun 25;279(26):27376-82. Epub 2004 Apr 12. PMID:15078870 doi:10.1074/jbc.M401031200
  • Rudberg PC, Tholander F, Thunnissen MM, Haeggstrom JZ. Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms. J Biol Chem. 2002 Jan 11;277(2):1398-404. Epub 2001 Oct 23. PMID:11675384 doi:10.1074/jbc.M106577200
  • Rudberg PC, Tholander F, Thunnissen MM, Samuelsson B, Haeggstrom JZ. Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4215-20. Epub 2002 Mar 26. PMID:11917124 doi:10.1073/pnas.072090099
  • Thunnissen MM, Nordlund P, Haeggstrom JZ. Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation. Nat Struct Biol. 2001 Feb;8(2):131-5. PMID:11175901 doi:10.1038/84117

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