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2aaz

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[[Image:2aaz.png|left|200px]]
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==About this Structure==
==About this Structure==
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2AAZ is a 16 chains structure of sequences from [http://en.wikipedia.org/wiki/Filobasidiella_neoformans Filobasidiella neoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAZ OCA].
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[[2aaz]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Filobasidiella_neoformans Filobasidiella neoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAZ OCA].
==Reference==
==Reference==
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[[Category: Nucleotide biosynthesis]]
[[Category: Nucleotide biosynthesis]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:00:55 2009''
 

Revision as of 21:23, 14 March 2011

Image:2aaz.png

Template:STRUCTURE 2aaz

Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate

Template:ABSTRACT PUBMED 16204883

About this Structure

2aaz is a 16 chain structure with sequence from Filobasidiella neoformans. Full crystallographic information is available from OCA.

Reference

  • Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1320-34. Epub 2005, Sep 28. PMID:16204883 doi:10.1107/S0907444905022638
  • Costi PM, Rinaldi M, Tondi D, Pecorari P, Barlocco D, Ghelli S, Stroud RM, Santi DV, Stout TJ, Musiu C, Marangiu EM, Pani A, Congiu D, Loi GA, La Colla P. Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. J Med Chem. 1999 Jun 17;42(12):2112-24. PMID:10377217 doi:10.1021/jm9900016
  • Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP. Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry. 1999 Feb 2;38(5):1607-17. PMID:9931028 doi:10.1021/bi9815896

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