2jgr
From Proteopedia
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| - | [[Image:2jgr.jpg|left|200px]]<br /><applet load="2jgr" size=" | + | [[Image:2jgr.jpg|left|200px]]<br /><applet load="2jgr" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2jgr, resolution 2.65Å" /> | caption="2jgr, resolution 2.65Å" /> | ||
'''CRYSTAL STRUCTURE OF YEGS IN COMPLEX WITH ADP'''<br /> | '''CRYSTAL STRUCTURE OF YEGS IN COMPLEX WITH ADP'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2JGR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with POP as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Pop Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2JGR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=POP:'>POP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Pop Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:34:22 2008'' |
Revision as of 12:34, 23 January 2008
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CRYSTAL STRUCTURE OF YEGS IN COMPLEX WITH ADP
Overview
The human lipid kinase family controls cell proliferation, differentiation, and tumorigenesis and includes diacylglycerol kinases, sphingosine kinases, and ceramide kinases. YegS is an Escherichia coli, protein with significant sequence homology to the catalytic domain of the, human lipid kinases. We have solved the crystal structure of YegS and, shown that it is a lipid kinase with phosphatidylglycerol kinase activity., The crystal structure reveals a two-domain protein with significant, structural similarity to a family of NAD kinases. The active site is, located in the interdomain cleft formed by four conserved sequence motifs., Surprisingly, the structure reveals a novel metal binding site composed of, residues conserved in most lipid kinases.
About this Structure
2JGR is a Single protein structure of sequence from Escherichia coli with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site., Bakali HM, Herman MD, Johnson KA, Kelly AA, Wieslander A, Hallberg BM, Nordlund P, J Biol Chem. 2007 Jul 6;282(27):19644-52. Epub 2007 Mar 11. PMID:17351295
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