1gsz

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[[Image:1gsz.png|left|200px]]
[[Image:1gsz.png|left|200px]]
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==About this Structure==
==About this Structure==
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1GSZ is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSZ OCA].
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[[1gsz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSZ OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:12031670</ref><references group="xtra"/>
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<ref group="xtra">PMID:12031670</ref><ref group="xtra">PMID:9931258</ref><ref group="xtra">PMID:9295270</ref><ref group="xtra">PMID:9070455</ref><ref group="xtra">PMID:9162756</ref><references group="xtra"/>
[[Category: Alicyclobacillus acidocaldarius]]
[[Category: Alicyclobacillus acidocaldarius]]
[[Category: Lenhart, A.]]
[[Category: Lenhart, A.]]
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[[Category: Monotopic membrane protein]]
[[Category: Monotopic membrane protein]]
[[Category: Oxidosqualene cyclase]]
[[Category: Oxidosqualene cyclase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:48:46 2009''
 

Revision as of 00:36, 15 March 2011

Template:STRUCTURE 1gsz

CRYSTAL STRUCTURE OF A SQUALENE CYCLASE IN COMPLEX WITH THE POTENTIAL ANTICHOLESTEREMIC DRUG RO48-8071

Template:ABSTRACT PUBMED 12031670

About this Structure

1gsz is a 3 chain structure with sequence from Alicyclobacillus acidocaldarius. Full crystallographic information is available from OCA.

Reference

  • Lenhart A, Weihofen WA, Pleschke AE, Schulz GE. Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071. Chem Biol. 2002 May;9(5):639-45. PMID:12031670
  • Wendt KU, Lenhart A, Schulz GE. The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution. J Mol Biol. 1999 Feb 12;286(1):175-87. PMID:9931258 doi:http://dx.doi.org/10.1006/jmbi.1998.2470
  • Wendt KU, Poralla K, Schulz GE. Structure and function of a squalene cyclase. Science. 1997 Sep 19;277(5333):1811-5. PMID:9295270
  • Wendt KU, Feil C, Lenhart A, Poralla K, Schulz GE. Crystallization and preliminary X-ray crystallographic analysis of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. Protein Sci. 1997 Mar;6(3):722-4. PMID:9070455 doi:10.1002/pro.5560060322
  • Morand OH, Aebi JD, Dehmlow H, Ji YH, Gains N, Lengsfeld H, Himber J. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J Lipid Res. 1997 Feb;38(2):373-90. PMID:9162756

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