Index.php/Sandbox Reserved 337
From Proteopedia
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=Structure= | =Structure= | ||
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==Function== | ==Function== | ||
Revision as of 20:29, 17 March 2011
Chorismate synthase
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| 1ztb, resolution 2.65Å () | |||||||||
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| Gene: | aroC, aroF (Mycobacterium tuberculosis) | ||||||||
| Activity: | Chorismate synthase, with EC number 4.2.3.5 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Chorismate Synthase is the last enzyme present in the shikimate pathway[1], a process which converts phosphoenolpyruvate, and erythrose 4-phosphate to chorismate in a series of seven steps.[2] The shikimate pathway is essential in the production of the amino acids phenylalanine, tryptophan and tyrosine, all essential amino acids.[3]
Structure
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Function
Mechanism
References
- ↑ Macheroux P, Schmid J, Amrhein N, Schaller A. A unique reaction in a common pathway: mechanism and function of chorismate synthase in the shikimate pathway. Planta. 1999 Jan;207(3):325-34. PMID:9951731
- ↑ Herrmann KM, Weaver LM. THE SHIKIMATE PATHWAY. Annu Rev Plant Physiol Plant Mol Biol. 1999 Jun;50:473-503. PMID:15012217 doi:10.1146/annurev.arplant.50.1.473
- ↑ Dias MV, Borges JC, Ely F, Pereira JH, Canduri F, Ramos CH, Frazzon J, Palma MS, Basso LA, Santos DS, de Azevedo WF Jr. Structure of chorismate synthase from Mycobacterium tuberculosis. J Struct Biol. 2006 May;154(2):130-43. Epub 2006 Jan 17. PMID:16459102 doi:10.1016/j.jsb.2005.12.008
- ↑ Ahn HJ, Yoon HJ, Lee B 2nd, Suh SW. Crystal structure of chorismate synthase: a novel FMN-binding protein fold and functional insights. J Mol Biol. 2004 Feb 27;336(4):903-15. PMID:15095868
