User:Jamie Abbott/Sandbox1
From Proteopedia
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| - | GCN5 catalyzes the transfer of an acetyl group from acetyl coenzyme A (<scene name='User:Jamie_Abbott/Sandbox1/Acetyl_coa_ligand/2'>Acetly CoA</scene>) onto the ε-amino group of specific lysine residues present in the amino-terminal tails of each of the core histones resulting in the neutralization of a single positive charge. | + | GCN5 catalyzes the transfer of an acetyl group from acetyl coenzyme A (<scene name='User:Jamie_Abbott/Sandbox1/Acetyl_coa_ligand/2'>Acetly CoA</scene>) onto the ε-amino group of specific lysine residues present in the amino-terminal tails of each of the core histones resulting in the neutralization of a single positive charge. <ref>PMID:10887202</ref><ref>PMID:11953458</ref> |
Revision as of 14:25, 19 April 2011
Contents |
Histone Acetyltransferase GCN5
Histone Acetyltransferase (HAT) GCN5 is a ~94 kD (837 amino acid) protein. It is a nuclear HAT or A-type HAT.
GCN5 catalyzes the acetylation of specific Lysine residues of histones H3 and H4. Histone acetylation is an important
HAT Domain
The HAT domain of human GCN5 consists of amino acid residues 496-658. This domain is a mixed alpha beta structure with 7 and seven anti-parallel .
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Catalysis
GCN5 catalyzes the transfer of an acetyl group from acetyl coenzyme A () onto the ε-amino group of specific lysine residues present in the amino-terminal tails of each of the core histones resulting in the neutralization of a single positive charge. [1][2]
Bromo Domain
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