2j0b
From Proteopedia
(New page: 200px<br /> <applet load="2j0b" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j0b, resolution 2.10Å" /> '''STRUCTURE OF THE CA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2J0B is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with SO4, K, MN and UDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.222 2.4.1.222]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J0B OCA]]. | + | 2J0B is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with SO4, K, MN and UDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/O-fucosylpeptide_3-beta-N-acetylglucosaminyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.222 2.4.1.222]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J0B OCA]]. |
==Reference== | ==Reference== | ||
Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16964258 16964258] | Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16964258 16964258] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| + | [[Category: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Chen, Y.W.]] | [[Category: Chen, Y.W.]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:55:37 2007'' |
Revision as of 09:50, 30 October 2007
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STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE
Overview
Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify, Notch receptors, altering their ligand-binding specificity to regulate, Notch signaling in development. We present the crystal structure of mouse, Manic Fringe bound to UDP and manganese. The structure reveals amino acid, residues involved in recognition of donor substrates and catalysis, and a, putative binding pocket for acceptor substrates. Mutations of several, invariant residues in this pocket impair Fringe activity in vivo.
About this Structure
2J0B is a [Single protein] structure of sequence from [Mus musculus] with SO4, K, MN and UDP as [ligands]. Active as [O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase], with EC number [2.4.1.222]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:16964258
Page seeded by OCA on Tue Oct 30 11:55:37 2007
Categories: Mus musculus | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | Single protein | Chen, Y.W. | Clausen, H. | Cohen, S.M. | Conti, E. | Jinek, M. | K | MN | SO4 | UDP | Developmental protein | Glycoprotein | Glycosyltransferase | Golgi apparatus | Membrane | Notch signaling | Signal-anchor | Transferase | Transmembrane
