1hxp
From Proteopedia
(New page: 200px<br /> <applet load="1hxp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hxp, resolution 1.8Å" /> '''NUCLEOTIDE TRANSFERA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1HXP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN, FE, BME, U5P and UDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.10 2.7.7.10]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HXP OCA]]. | + | 1HXP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN, FE, BME, U5P and UDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/UTP--hexose-1-phosphate_uridylyltransferase UTP--hexose-1-phosphate uridylyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.10 2.7.7.10]]. Structure known Active Sites: FR2, FRN, NU2, NUC, ZN2 and ZNC. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HXP OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: UTP--hexose-1-phosphate uridylyltransferase]] | ||
[[Category: Frey, P.A.]] | [[Category: Frey, P.A.]] | ||
[[Category: Rayment, I.]] | [[Category: Rayment, I.]] | ||
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[[Category: nucleotidyl transferase]] | [[Category: nucleotidyl transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:55:58 2007'' |
Revision as of 09:51, 30 October 2007
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NUCLEOTIDE TRANSFERASE
Overview
Galactose-1-phosphate uridylyltransferase catalyzes the reversible, transfer of the uridine 5'-monophosphoryl moiety of UDP-glucose to the, phosphate group of galactose 1-phosphate to form UDP-galactose. This, enzyme participates in the Leloir pathway of galactose metabolism, and its, absence is the primary cause of the potentially lethal disease, galactosemia. The three-dimensional structure of the dimeric enzyme from, Escherichia coli complexed with uridine 5'-diphosphate is reported here., The structure was solved by multiple isomorphous replacement and electron, density modification techniques and has been refined to 1.8 A resolution., Enzyme subunits consist of a single domain with the topology of a, "half-barrel". The barrel staves are formed by nine strands of, antiparallel ... [(full description)]
About this Structure
1HXP is a [Single protein] structure of sequence from [Escherichia coli] with ZN, FE, BME, U5P and UDP as [ligands]. Active as [UTP--hexose-1-phosphate uridylyltransferase], with EC number [2.7.7.10]. Structure known Active Sites: FR2, FRN, NU2, NUC, ZN2 and ZNC. Full crystallographic information is available from [OCA].
Reference
Three-dimensional structure of galactose-1-phosphate uridylyltransferase from Escherichia coli at 1.8 A resolution., Wedekind JE, Frey PA, Rayment I, Biochemistry. 1995 Sep 5;34(35):11049-61. PMID:7669762
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