Samantha Stone Sandbox

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Current revision (04:17, 22 April 2011) (edit) (undo)
 
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==This is a placeholder==
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This is the 3FPB Membrane Protein.
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This is a placeholder text to help you get started in
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placing a Jmol applet on your page. At any time, click
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"Show Preview" at the bottom of this page to see how it goes.
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Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
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Its structure consists of ATP, adenosine 5'-(beta,gamma-methylene)triphosphate (AMPPCP), and cyclopiazonic acid (CZA). A metal (Mg or Mn) must react in the ATP binding site for CZA to bind and react. This occurs at the M1 helix. Knowing the structure of the binding site allows for drugs that can be designed to target this ATPase.
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and display another structure.
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{{STRUCTURE_3cin | PDB=3cin | SCENE= }}
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{{STRUCTURE_3fpb | PDB=3fpb | SCENE= }}
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<scene name='Samantha_Stone_Sandbox/Mg_ii_binding_site/2'>Full Molecule</scene>
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<scene name='Samantha_Stone_Sandbox/Mg_ii_binding_site/1'>Mg II Binding Site</scene>
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<scene name='Samantha_Stone_Sandbox/Membrane_spanning/1'>Membrane Spanning</scene>
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<scene name='Samantha_Stone_Sandbox/Atp_binding_site_label/2'>ATP Binding Site</scene>
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<scene name='Samantha_Stone_Sandbox/Atp_binding_site_label/3'>Mg II ATP Binding Site</scene>
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<scene name='Samantha_Stone_Sandbox/Cza_binding_site_label/1'>CZA Binding Site</scene>
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<scene name='Samantha_Stone_Sandbox/Cza_binding_site_label/1'>Mg II CZA Binding Site</scene>
<scene name='Samantha_Stone_Sandbox/Mn_ii_binding_site/1'>Mn II Binding Site</scene>
<scene name='Samantha_Stone_Sandbox/Mn_ii_binding_site/1'>Mn II Binding Site</scene>
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<scene name='Samantha_Stone_Sandbox/Mn_cza__ii_binding_site/1'>Mn II CZA Binding Site</scene>
<scene name='Samantha_Stone_Sandbox/Mn_cza__ii_binding_site/1'>Mn II CZA Binding Site</scene>
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The following picture shows the M1-M10 helices that are involved sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA). The M1 helix has a kink that is a part of all P-type ATPases. This kink is involved in cytoplasmic cation access pathway. The metal ion needed for binding can also be seen.
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http://www.jbc.org/content/284/20/13513/F1.large.jpg

Current revision

This is the 3FPB Membrane Protein.

Its structure consists of ATP, adenosine 5'-(beta,gamma-methylene)triphosphate (AMPPCP), and cyclopiazonic acid (CZA). A metal (Mg or Mn) must react in the ATP binding site for CZA to bind and react. This occurs at the M1 helix. Knowing the structure of the binding site allows for drugs that can be designed to target this ATPase.


PDB ID 3fpb

Drag the structure with the mouse to rotate
3fpb, resolution 2.55Å ()
Ligands: , , , ,
Activity: Calcium-transporting ATPase, with EC number 3.6.3.8
Related: 2o9j, 3fgo
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml




The following picture shows the M1-M10 helices that are involved sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA). The M1 helix has a kink that is a part of all P-type ATPases. This kink is involved in cytoplasmic cation access pathway. The metal ion needed for binding can also be seen.

F1.large.jpg

Proteopedia Page Contributors and Editors (what is this?)

Samantha Stone, Karsten Theis

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