Samantha Stone Sandbox
From Proteopedia
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| - | <scene name='Samantha_Stone_Sandbox/Mg_ii_binding_site/2'>Full | + | This is the 3FPB Membrane Protein. |
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| + | Its structure consists of ATP, adenosine 5'-(beta,gamma-methylene)triphosphate (AMPPCP), and cyclopiazonic acid (CZA). A metal (Mg or Mn) must react in the ATP binding site for CZA to bind and react. This occurs at the M1 helix. Knowing the structure of the binding site allows for drugs that can be designed to target this ATPase. | ||
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| + | {{STRUCTURE_3fpb | PDB=3fpb | SCENE= }} | ||
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| + | <scene name='Samantha_Stone_Sandbox/Mg_ii_binding_site/2'>Full Molecule</scene> | ||
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| + | <scene name='Samantha_Stone_Sandbox/Membrane_spanning/1'>Membrane Spanning</scene> | ||
<scene name='Samantha_Stone_Sandbox/Atp_binding_site_label/3'>Mg II ATP Binding Site</scene> | <scene name='Samantha_Stone_Sandbox/Atp_binding_site_label/3'>Mg II ATP Binding Site</scene> | ||
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<scene name='Samantha_Stone_Sandbox/Mn_cza__ii_binding_site/1'>Mn II CZA Binding Site</scene> | <scene name='Samantha_Stone_Sandbox/Mn_cza__ii_binding_site/1'>Mn II CZA Binding Site</scene> | ||
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| + | The following picture shows the M1-M10 helices that are involved sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA). The M1 helix has a kink that is a part of all P-type ATPases. This kink is involved in cytoplasmic cation access pathway. The metal ion needed for binding can also be seen. | ||
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| + | http://www.jbc.org/content/284/20/13513/F1.large.jpg | ||
Current revision
This is the 3FPB Membrane Protein.
Its structure consists of ATP, adenosine 5'-(beta,gamma-methylene)triphosphate (AMPPCP), and cyclopiazonic acid (CZA). A metal (Mg or Mn) must react in the ATP binding site for CZA to bind and react. This occurs at the M1 helix. Knowing the structure of the binding site allows for drugs that can be designed to target this ATPase.
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| 3fpb, resolution 2.55Å () | |||||||
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| Ligands: | , , , , | ||||||
| Activity: | Calcium-transporting ATPase, with EC number 3.6.3.8 | ||||||
| Related: | 2o9j, 3fgo | ||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The following picture shows the M1-M10 helices that are involved sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA). The M1 helix has a kink that is a part of all P-type ATPases. This kink is involved in cytoplasmic cation access pathway. The metal ion needed for binding can also be seen.
