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2cd7
From Proteopedia
(New page: 200px<br /> <applet load="2cd7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cd7, resolution 1.50Å" /> '''STAPHYLOCOCCUS AURE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CD7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] with NA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.97.1.5 1.97.1.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]]. | + | 2CD7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] with NA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_1.20.4.1 Transferred entry: 1.20.4.1]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.97.1.5 1.97.1.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
| + | [[Category: Transferred entry: 1.20.4.1]] | ||
[[Category: Belle, K.Van.]] | [[Category: Belle, K.Van.]] | ||
[[Category: Brosens, E.]] | [[Category: Brosens, E.]] | ||
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[[Category: redox-active center]] | [[Category: redox-active center]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:57:19 2007'' |
Revision as of 09:52, 30 October 2007
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STAPHYLOCOCCUS AUREUS PI258 ARSENATE REDUCTASE (ARSC) H62Q MUTANT
Overview
In the thioredoxin (Trx)-coupled arsenate reductase family, arsenate, reductase from Staphylococcus aureus plasmid pI258 (Sa_ArsC) and from, Bacillus subtilis (Bs_ArsC) are structurally related detoxification, enzymes. Catalysis of the reduction of arsenate to arsenite involves a, P-loop (Cys10Thr11Gly12Asn13Ser14Cys15Arg16) structural motif and a, disulphide cascade between three conserved cysteine residues (Cys10, Cys82, and Cys89). For its activity, Sa_ArsC benefits from the binding of, tetrahedral oxyanions in the P-loop active site and from the binding of, potassium in a specific cation-binding site. In contrast, the steady-state, kinetic parameters of Bs_ArsC are not affected by sulphate or potassium., The commonly occurring mutation of a histidine (H62), located about 6 A, from the ... [(full description)]
About this Structure
2CD7 is a [Single protein] structure of sequence from [Staphylococcus aureus] with NA as [ligand]. Active as [Transferred entry: 1.20.4.1], with EC number [1.97.1.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Interplay between ion binding and catalysis in the thioredoxin-coupled arsenate reductase family., Roos G, Buts L, Van Belle K, Brosens E, Geerlings P, Loris R, Wyns L, Messens J, J Mol Biol. 2006 Jul 21;360(4):826-38. Epub 2006 Jun 6. PMID:16797027
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