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Adrenergic receptor
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{{STRUCTURE_2rh1| PDB=2rh1 | SIZE=300| SCENE=Beta-2_Adrenergic_Receptor/Opening/1 |right|CAPTION=Beta-2 Adrenergic Receptor, [[2rh1]] }} | {{STRUCTURE_2rh1| PDB=2rh1 | SIZE=300| SCENE=Beta-2_Adrenergic_Receptor/Opening/1 |right|CAPTION=Beta-2 Adrenergic Receptor, [[2rh1]] }} | ||
| - | [[Adrenergic receptor]]. The images at the left and at the right correspond to one representative Adrenergic receptor, ''i.e.'' the crystal structure of human Beta-2_Adrenergic_Receptor ([[2rh1]]). '''See also [[Beta-2 Adrenergic Receptor]].''' | + | The [[Adrenergic receptor|adrenergic receptors]] are metabolic G protein-coupled receptors. They are the targets of catecholamines. The binding of an agonist to them causes a sympathetic response. The α-2 adrenergic receptor (A2AR) inhibits insulin or glucagons release. The β-1 adrenergic receptor (B1AR) increases cardiac output and secretion of rennin and ghrelin. The β-2 adrenergic receptor (B2AR) triggers many relaxation reactions. The images at the left and at the right correspond to one representative Adrenergic receptor, ''i.e.'' the crystal structure of human Beta-2_Adrenergic_Receptor ([[2rh1]]). '''See also [[Beta-2 Adrenergic Receptor]].''' |
Revision as of 10:52, 12 May 2011
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| Beta-2 Adrenergic Receptor, 2rh1 | |||||||||
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| Ligands: | , , , , , , , | ||||||||
| Gene: | ADRB2, ADRB2R, B2AR / E (Enterobacteria phage T4) | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
The adrenergic receptors are metabolic G protein-coupled receptors. They are the targets of catecholamines. The binding of an agonist to them causes a sympathetic response. The α-2 adrenergic receptor (A2AR) inhibits insulin or glucagons release. The β-1 adrenergic receptor (B1AR) increases cardiac output and secretion of rennin and ghrelin. The β-2 adrenergic receptor (B2AR) triggers many relaxation reactions. The images at the left and at the right correspond to one representative Adrenergic receptor, i.e. the crystal structure of human Beta-2_Adrenergic_Receptor (2rh1). See also Beta-2 Adrenergic Receptor.
Contents |
3D Structures of Adrenergic receptor
Alpha-2 adrenergic receptor
3kj6, 2r4r, 2r4s – hB2AR + FAB heavy+light chains
1ho9, 1hod – hA2AR peptide (mutant) – NMR
1hof, 1hll - hA2AR peptide – NMR
Beta-1 adrenergic receptor
2y01 – tB1AR fragment (mutant) – turkey
1dep – tB1AR peptide - NMR
2y00, 2y02, 2y03, 2y04, 2vt4 - tB1AR fragment (mutant) + agonist
Beta-2 adrenergic receptor
See also Beta-2 Adrenergic Receptor
3pds - hB2AR/T4 lysozyme - human
3p0g – hB2AR/T4 lysozyme + cameloid antibody fragment
2rh1 - hB2AR/T4 lysozyme (mutant)
3d4s - hB2AR/T4 lysozyme (mutant) + cholesterol
3ny8, 3ny9, 3nya – hB2AR + agonist
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Wayne Decatur, Karsten Theis, Alexander Berchansky
