Aspartate-semialdehyde dehydrogenase
From Proteopedia
(New page: Crystal Structure of Aspartate-semialdehyde dehydrogenase, 1mc4 {{STRUCTURE_1mc4| PDB=1mc4 | SIZE=300| SCENE= |right|CAPTION=Aspartate-semialdehyd...) |
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[[Image:1mc4.png|left|200px|thumb|Crystal Structure of Aspartate-semialdehyde dehydrogenase, [[1mc4]]]] | [[Image:1mc4.png|left|200px|thumb|Crystal Structure of Aspartate-semialdehyde dehydrogenase, [[1mc4]]]] | ||
{{STRUCTURE_1mc4| PDB=1mc4 | SIZE=300| SCENE= |right|CAPTION=Aspartate-semialdehyde dehydrogenase, [[1mc4]] }} | {{STRUCTURE_1mc4| PDB=1mc4 | SIZE=300| SCENE= |right|CAPTION=Aspartate-semialdehyde dehydrogenase, [[1mc4]] }} | ||
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| + | [[Aspartate-semialdehyde dehydrogenase]] (ASADH) is an enzyme which is part of the biosynthesis of amino acids. It catalyzes the conversion of L-aspartate 4-semialdehyde (ASA) + phosphate + NADP to L-4-aspartyl phosphate + NADPH + H+. The images at the left and at the right correspond to one representative ASADH, ''i.e.'' the crystal structure of Aspartate-semialdehyde dehydrogenase from ''Vibrio cholerae'' ([[1mc4]]). | ||
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| + | == 3D Structures of Aspartate-semialdehyde dehydrogenase == | ||
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| + | [[2qz9]], [[1mc4]] – VcASADH II – ''Vibrio cholerae''<br /> | ||
| + | [[2yv3]] – ASADH – ''Thermus thermiphilus''<br /> | ||
| + | [[1t4d]], [[1t4b]], [[1brm]] - EcASADH β - ''Escherichia coli''<br /> | ||
| + | [[1pu2]], [[1oza]] - HiASADH (mutant) – ''Haemophilus influenzae''<br /> | ||
| + | [[1nwc]] – HiASADH<br /> | ||
| + | [[1nwh]] – HiASADH reaction intermediate<br /> | ||
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| + | ===ASADH binary complex=== | ||
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| + | [[2r00]] - VcASADH II + ASA<br /> | ||
| + | [[3llg]] – ASADH + glycerot + Pi – ''Mycobacterium tuberculosis''<br /> | ||
| + | [[3hsk]] – ASADH + NADP – ''Candida albicans''<br /> | ||
| + | [[1ys4]] - ASADH + NADP – ''Methanocaldococcus jannaschii''<br /> | ||
| + | [[1nx6]] - HiASADH reaction intermediate +Pi<br /> | ||
| + | [[1ta4]] - HiASADH + As<br /> | ||
| + | [[1tb4]] - HiASADH + IO4<br /> | ||
| + | [[1q2x]] - HiASADH (mutant) + ASA<br /> | ||
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| + | ===ASADH ternary complex=== | ||
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| + | [[1pqu]] - HiASADH (mutant) + NADP + cacodylate + substrate analog<br /> | ||
| + | [[1pqp]] - HiASADH (mutant) + ASA + Pi<br /> | ||
| + | [[1gl3]] - EcASADH β + NADP + substrate analog<br /> | ||
| + | [[1mb4]] - VcASADH + NADP + substrate analog<br /> | ||
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| + | [[Category:Topic Page]] | ||
Revision as of 10:15, 9 June 2011
Aspartate-semialdehyde dehydrogenase (ASADH) is an enzyme which is part of the biosynthesis of amino acids. It catalyzes the conversion of L-aspartate 4-semialdehyde (ASA) + phosphate + NADP to L-4-aspartyl phosphate + NADPH + H+. The images at the left and at the right correspond to one representative ASADH, i.e. the crystal structure of Aspartate-semialdehyde dehydrogenase from Vibrio cholerae (1mc4).
Contents |
3D Structures of Aspartate-semialdehyde dehydrogenase
2qz9, 1mc4 – VcASADH II – Vibrio cholerae
2yv3 – ASADH – Thermus thermiphilus
1t4d, 1t4b, 1brm - EcASADH β - Escherichia coli
1pu2, 1oza - HiASADH (mutant) – Haemophilus influenzae
1nwc – HiASADH
1nwh – HiASADH reaction intermediate
ASADH binary complex
2r00 - VcASADH II + ASA
3llg – ASADH + glycerot + Pi – Mycobacterium tuberculosis
3hsk – ASADH + NADP – Candida albicans
1ys4 - ASADH + NADP – Methanocaldococcus jannaschii
1nx6 - HiASADH reaction intermediate +Pi
1ta4 - HiASADH + As
1tb4 - HiASADH + IO4
1q2x - HiASADH (mutant) + ASA
ASADH ternary complex
1pqu - HiASADH (mutant) + NADP + cacodylate + substrate analog
1pqp - HiASADH (mutant) + ASA + Pi
1gl3 - EcASADH β + NADP + substrate analog
1mb4 - VcASADH + NADP + substrate analog
