Group:MUZIC:ANKRD2

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==Your Heading Here (maybe something like 'Structure')==<StructureSection load='1dq8' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''>Anything in this section will appear adjacent to the 3D structure and will be scrollable.</StructureSection>
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==Your Heading Here (maybe something like 'Structure')==<StructureSection load='1dq8' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''>Anything in this section will appear adjacent to the 3D structure and will be scrollable.</StructureSection>
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Spyros D. Chatziefthimiou, Ph.D.
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European Molecular Biology Laboratory
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Building 25A, c/o DESY
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Notkestraße 85
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22603 Hamburg
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Germany
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Tel: +49 40 89902247
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Fax: +49 40 89902149
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spchatzi@embl-hamburg.de

Revision as of 10:48, 24 June 2011

ANKRD2

Human AKRD2 (ankyrin repeat domain 2) encodes a 37 kDa protein, found in slow muscle fibers. It belongs to the conserved muscle ankyrin repeat protein (MARP) family. It forms a link between the sarcomere and nucleus in skeletal muscle and is involved in striated muscle hypertrophy. AnkrD2 interacts with telethonin and the transcription factors YB-1, PML and p53.[1]

Structure of a designed ankyrin repeat protein (DARPin) with five ankyrin repeat motifs (2QYJ)

Drag the structure with the mouse to rotate









References:

  1. ↑ Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G. The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. J Mol Biol. 2004 May 28;339(2):313-25. PMID:15136035 doi:10.1016/j.jmb.2004.03.071

-- Spyros D. Chatziefthimiou, Ph.D.

European Molecular Biology Laboratory Building 25A, c/o DESY Notkestraße 85 22603 Hamburg Germany

Tel: +49 40 89902247 Fax: +49 40 89902149

spchatzi@embl-hamburg.de

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