Group:MUZIC:ANKRD2

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Revision as of 10:58, 24 June 2011

ANKRD2

Human AKRD2 (ankyrin repeat domain 2) encodes a 37 kDa protein, found in slow muscle fibers. It belongs to the conserved muscle ankyrin repeat protein (MARP) family. It forms a link between the sarcomere and nucleus in skeletal muscle and is involved in striated muscle hypertrophy. AnkrD2 interacts with telethonin and the transcription factors YB-1, PML and p53.[1]

Structure of a designed ankyrin repeat protein (DARPin) with five ankyrin repeat motifs (2QYJ)

Drag the structure with the mouse to rotate









References:

  1. ↑ Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G. The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. J Mol Biol. 2004 May 28;339(2):313-25. PMID:15136035 doi:10.1016/j.jmb.2004.03.071
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