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1dff
From Proteopedia
(New page: 200px<br /> <applet load="1dff" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dff, resolution 2.88Å" /> '''PEPTIDE DEFORMYLASE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1DFF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.31 3.5.1.31]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DFF OCA]]. | + | 1DFF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Formylmethionine_deformylase Formylmethionine deformylase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.31 3.5.1.31]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DFF OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of the Escherichia coli peptide deformylase., Chan MK, Gong W, Rajagopalan PT, Hao B, Tsai CM, Pei D, Biochemistry. 1997 Nov 11;36(45):13904-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9374869 9374869] | Crystal structure of the Escherichia coli peptide deformylase., Chan MK, Gong W, Rajagopalan PT, Hao B, Tsai CM, Pei D, Biochemistry. 1997 Nov 11;36(45):13904-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9374869 9374869] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| + | [[Category: Formylmethionine deformylase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Chan, M.K.]] | [[Category: Chan, M.K.]] | ||
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[[Category: zinc metalloprotease]] | [[Category: zinc metalloprotease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:10:31 2007'' |
Revision as of 10:05, 30 October 2007
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PEPTIDE DEFORMYLASE
Overview
Protein synthesis in bacteria involves the formylation and deformylation, of the N-terminal methionine. As eukaryotic organisms differ in their, protein biosynthetic mechanisms, peptide deformylase, the bacterial enzyme, responsible for deformylation, represents a potential target for, antibiotic studies. Here we report the crystallization and 2.9 A X-ray, structure solution of the zinc containing Escherichia coli peptide, deformylase. While the primary sequence, tertiary structure, and use of, coordinated cysteine suggest that E. coli deformylase belongs to a new, subfamily of metalloproteases, the environment around the metal appears to, have strong geometric similarity to the active sites of the thermolysin, family. This suggests a possible similarity in their hydrolytic, mechanisms. ... [(full description)]
About this Structure
1DFF is a [Single protein] structure of sequence from [Escherichia coli] with ZN as [ligand]. Active as [Formylmethionine deformylase], with EC number [3.5.1.31]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the Escherichia coli peptide deformylase., Chan MK, Gong W, Rajagopalan PT, Hao B, Tsai CM, Pei D, Biochemistry. 1997 Nov 11;36(45):13904-9. PMID:9374869
Page seeded by OCA on Tue Oct 30 12:10:31 2007
