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Group:MUZIC:Nebulin
From Proteopedia
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==Introduction== | ==Introduction== | ||
<StructureSection load='1ark' size='500' side='right' caption='NMR structure of the SH3 domain of Nebulin' scene='User:Marie-Cecile_Pelissier/Workbench/Nebulin/Overall/2' | <StructureSection load='1ark' size='500' side='right' caption='NMR structure of the SH3 domain of Nebulin' scene='User:Marie-Cecile_Pelissier/Workbench/Nebulin/Overall/2' | ||
| - | >Nebulin (UniProt ID: P20929 [http://www.uniprot.org/uniprot/P20929]) is a very large filamentous protein (600-900 kDa)<ref> PMID 6547565</ref>tightly associated to the thin filament of the muscle sarcomere throughout its length. Nebulin is mostly found within the sarcomeres of skeletal muscles but was also identified at a low level in cardiac muscle cells<ref>PMID 12729758</ref>. Indeed, the sarcomeres of cardiac muscles predominantly contain a Nebulin-like protein called Nebulette (UniProt ID: O76041 [http://www.uniprot.org/uniprot/O76041]) which is a "short version" of Nebulin, highly similar to its C-terminal part <ref> PMID 8581976</ref>. | + | >Nebulin (UniProt ID: P20929 [http://www.uniprot.org/uniprot/P20929]) is a very large filamentous protein (600-900 kDa) <ref>PMID 6547565</ref> tightly associated to the thin filament of the muscle sarcomere throughout its length. Nebulin is mostly found within the sarcomeres of skeletal muscles but was also identified at a low level in cardiac muscle cells <ref>PMID 12729758</ref>. Indeed, the sarcomeres of cardiac muscles predominantly contain a Nebulin-like protein called Nebulette (UniProt ID: O76041 [http://www.uniprot.org/uniprot/O76041]) which is a "short version" of Nebulin, highly similar to its C-terminal part <ref>PMID 8581976</ref>. |
Revision as of 16:17, 1 July 2011
Contents |
Introduction
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Domains and interactions
Glutamic rich region
Nebulin modules
Serine rich region
SH3 domain
The Nebulin SH3 domain adopts a ß-Barrel .
References
- ↑ Wang K. Cytoskeletal matrix in striated muscle: the role of titin, nebulin and intermediate filaments. Adv Exp Med Biol. 1984;170:285-305. PMID:6547565
- ↑ Kazmierski ST, Antin PB, Witt CC, Huebner N, McElhinny AS, Labeit S, Gregorio CC. The complete mouse nebulin gene sequence and the identification of cardiac nebulin. J Mol Biol. 2003 May 9;328(4):835-46. PMID:12729758
- ↑ Moncman CL, Wang K. Nebulette: a 107 kD nebulin-like protein in cardiac muscle. Cell Motil Cytoskeleton. 1995;32(3):205-25. PMID:8581976 doi:http://dx.doi.org/10.1002/cm.970320305
- ↑ Ottenheijm CA, Granzier H. Lifting the nebula: novel insights into skeletal muscle contractility. Physiology (Bethesda). 2010 Oct;25(5):304-10. PMID:20940435 doi:10.1152/physiol.00016.2010
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Marie-Cecile Pelissier, Michal Harel, Jaime Prilusky, Nikos Pinotsis
