Group:MUZIC:Enigma Family
From Proteopedia
m |
m |
||
| Line 1: | Line 1: | ||
=='''Enigma family: PDZ- and LIM-domain protein of the cytoskeleton'''== | =='''Enigma family: PDZ- and LIM-domain protein of the cytoskeleton'''== | ||
| - | Three proteins have extensively been described and characterized within this subfamily: '''Enigma''', '''Enigma Homologue''' (ENH) protein and '''ZASP/Cypher''' ('ZASP' being the human orthologue of 'Cypher' which is found in mouse and also identified by independent researchers who named it 'Oracle'). | + | Three proteins have extensively been described and characterized within this subfamily: '''Enigma''', '''Enigma Homologue''' (ENH) protein and '''ZASP/Cypher''' ('ZASP'<ref>PMID:10427098</ref> being the human orthologue of 'Cypher'<ref>PMID:10391924</ref> which is found in mouse and also identified by independent researchers who named it 'Oracle'<ref>PMID:10727866</ref>). |
| - | Didactically, protein members of the enigma subfamily typically possess within their structure: '''(1)''' an N-terminal PDZ domain (a domain which is named after the first three proteins where it was initially characterized i.e. '''P'''SD 95, '''D'''isc large protein and '''Z'''onula Occludens 1), and '''(2)''' three C-terminal LIM domain (a domain which is named after the first three proteins where it was characterized i.e. '''L'''in-11, '''I'''sl1 and '''M'''ec-3). | + | Didactically, protein members of the enigma subfamily typically possess within their structure: '''(1)''' an N-terminal PDZ domain (a domain which is named after the first three proteins where it was initially characterized i.e. '''P'''SD 95, '''D'''isc large protein and '''Z'''onula Occludens 1), and '''(2)''' three C-terminal LIM domain (a domain which is named after the first three proteins where it was characterized i.e. '''L'''in-11, '''I'''sl1 and '''M'''ec-3)<ref>PMID:20042479</ref>. |
| - | The member proteins have all been located to the mammalian striated muscle, specifically in the heart and skeletal muscle Z-disk. They interact via their PDZ domains with motor protein components of the Z-disk and also recruit signalling molecules via thier LIM domain or internal motifs, for example ''ZM motif'' (ZASP-like motif which is sandwiched between the PDZ- and LIM-domains in ZASP). | + | The member proteins have all been located to the mammalian striated muscle, specifically in the heart and skeletal muscle Z-disk. They interact via their PDZ domains with motor protein components of the Z-disk and also recruit signalling molecules via thier LIM domain or internal motifs, for example ''ZM motif'' (ZASP-like motif which is sandwiched between the PDZ- and LIM-domains in ZASP)<ref>doi:10.1161/CIRCRESAHA.110.225615</ref>. |
| - | These interactions via their PDZ- and LIM-domains have been suggested to be important for | + | These interactions via their PDZ- and LIM-domains have been suggested to be important for targeting and maintaining protein complexes in the sarcomere in order to maintain a proper architecture and physiologically functional muscle.<Structure load='1wf7' size='400' frame='true' align='right' caption='NMR structure of the PDZ domain of ENH protein' scene='User:Adekunle_Onipe/workbench/Enigma_Family/Enh_pdz/2'/> |
=='''''Enigma'''''== | =='''''Enigma'''''== | ||
| Line 41: | Line 41: | ||
=='''References'''== | =='''References'''== | ||
| + | <references/> | ||
> | > | ||
Revision as of 07:24, 5 July 2011
Contents |
Enigma family: PDZ- and LIM-domain protein of the cytoskeleton
Three proteins have extensively been described and characterized within this subfamily: Enigma, Enigma Homologue (ENH) protein and ZASP/Cypher ('ZASP'[1] being the human orthologue of 'Cypher'[2] which is found in mouse and also identified by independent researchers who named it 'Oracle'[3]).
Didactically, protein members of the enigma subfamily typically possess within their structure: (1) an N-terminal PDZ domain (a domain which is named after the first three proteins where it was initially characterized i.e. PSD 95, Disc large protein and Zonula Occludens 1), and (2) three C-terminal LIM domain (a domain which is named after the first three proteins where it was characterized i.e. Lin-11, Isl1 and Mec-3)[4].
The member proteins have all been located to the mammalian striated muscle, specifically in the heart and skeletal muscle Z-disk. They interact via their PDZ domains with motor protein components of the Z-disk and also recruit signalling molecules via thier LIM domain or internal motifs, for example ZM motif (ZASP-like motif which is sandwiched between the PDZ- and LIM-domains in ZASP)[5].
These interactions via their PDZ- and LIM-domains have been suggested to be important for targeting and maintaining protein complexes in the sarcomere in order to maintain a proper architecture and physiologically functional muscle.
|
Enigma
Structure
Interactions within the Z-disk
Functions
Enigma Homologue (ENH) protein
Structure
Interaction within the Z-disk
Functions
ZASP/Cypher/Oracle
Structure
Interactions within the Z-disk
Functions
References
- ↑ Faulkner G, Pallavicini A, Formentin E, Comelli A, Ievolella C, Trevisan S, Bortoletto G, Scannapieco P, Salamon M, Mouly V, Valle G, Lanfranchi G. ZASP: a new Z-band alternatively spliced PDZ-motif protein. J Cell Biol. 1999 Jul 26;146(2):465-75. PMID:10427098
- ↑ Zhou Q, Ruiz-Lozano P, Martone ME, Chen J. Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C. J Biol Chem. 1999 Jul 9;274(28):19807-13. PMID:10391924
- ↑ Passier R, Richardson JA, Olson EN. Oracle, a novel PDZ-LIM domain protein expressed in heart and skeletal muscle. Mech Dev. 2000 Apr;92(2):277-84. PMID:10727866
- ↑ Zheng M, Cheng H, Banerjee I, Chen J. ALP/Enigma PDZ-LIM domain proteins in the heart. J Mol Cell Biol. 2010 Apr;2(2):96-102. Epub 2009 Dec 30. PMID:20042479 doi:10.1093/jmcb/mjp038
- ↑ Wang X, Su H. Unraveling enigma in the z-disks. Circ Res. 2010 Aug 6;107(3):321-3. PMID:20689070 doi:10.1161/CIRCRESAHA.110.225615
>
