Group:MUZIC:XIN

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(New page: '''Xin actin-binding repeat-containing protein 1''' (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) synohas an actin-binding domain (ABD...)
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'''Xin actin-binding repeat-containing protein 1''' (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) synohas an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. '''Filamin B (FLNB)''' is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development. '''Filamin C (FLNC)''' is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain. The images at the left and at the right correspond to one representative filamin structure, ''i.e.'' the crystal structure of human filamin A ([[3hop]]), it forms a <scene name='Filamin/Cv/2'>dimer</scene> <ref>PMID:19773341</ref>. Two phosphate ions are rendered as space filling objects.
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'''Xin actin-binding repeat-containing protein 1''' (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.
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== Filamin A ==
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== Sequence Annotation ==
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[[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD<br />
[[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD<br />
[[3hoc]] – hFLNA ABD (mutant)<br />
[[3hoc]] – hFLNA ABD (mutant)<br />
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[[2aav]] - hFLNA domain 17 – NMR<br />
 
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[[2bp3]] - hFLNA domain 17+GPIB peptide<br />
 
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[[2k7p]] – hFLNA domains 16-17<br />
 
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[[2k7q]] - hFLNA domains 18-19<br />
 
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[[2j3s]] - hFLNA domains 19-21<br />
 
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[[2w0p]] - hFLNA domain 21+migfilin peptide<br />
 
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[[2jf1]], [[2brq]] - hFLNA domain 21+integrin peptide<br />
 
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[[2k3t]] - hFLNA domain 23 – NMR<br />
 
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[[3cnk]] - hFLNA DD<br />
 
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== Filamin B ==
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== Function ==
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== Interactions with other proteins ==
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== Filamin C ==
 
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[[2k9u]] – hFLNC+migfilin peptide<br />
 
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[[2d7m]], [[2d7n]], [[2d7o]], [[2d7p]] - hFLNC domains 14, 16, 17, 22 - NMR<br />
 
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[[2nqc]] - hFLNC domain 21<br />
 
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[[2d7q]] - hFLNC domain 23 – NMR<br />
 
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[[1v05]] - hFLNC DD<br />
 
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== Clinical significance ==
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== Other Filamins ==
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[[1wlh]], [[1qfh]] – FLN rod domain – ''Dictyostelium discoideum''<br />
[[1wlh]], [[1qfh]] – FLN rod domain – ''Dictyostelium discoideum''<br />
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==References==
==References==

Revision as of 07:50, 5 July 2011

Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.

Contents

Sequence Annotation

3isw – hFLNA repeat 21+CFTR peptide – human
2wfn, 3hop, 3hor – hFLNA ABD
3hoc – hFLNA ABD (mutant)


Function

Interactions with other proteins

2wa5, 3fer, 2eea - hFLNB ABD
2wa6, 2wa7 - hFLNB ABD (mutant)
2di9, 2dia, 2dib, 2dic, 2dj4, 2e9j, 2dmb, 2ee9, 2ee7, 2dmc, 2di8, 2dlg, 2e9i, 2ee6, 2eeb, 2eec, 2eed - hFLNB domains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 20, 21, 22, 23, 24 – NMR



Clinical significance

1wlh, 1qfh – FLN rod domain – Dictyostelium discoideum



References

http://www.uniprot.org/uniprot/Q702N8

Proteopedia Page Contributors and Editors (what is this?)

Georg Mlynek, Nikos Pinotsis, Jaime Prilusky

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