Group:MUZIC:XIN

[[Image:3hop.png|left|200px|thumb|Crystal structure of Human Filamin A, [[3hop]]]]

{{STRUCTURE_3hop| PDB=3hop | SIZE=300| SCENE=Filamin/Cv/1 |right|CAPTION=Human Filamin A, [[3hop]] }}

[[Filamin]] '''A (FLNA)''' has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. '''Filamin B (FLNB)''' is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development. '''Filamin C (FLNC)''' is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain. The images at the left and at the right correspond to one representative filamin structure, ''i.e.'' the crystal structure of human filamin A ([[3hop]]), it forms a <scene name='Filamin/Cv/2'>dimer</scene> <ref>PMID:19773341</ref>. Two phosphate ions are rendered as space filling objects.

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== Filamin A ==

[[3isw]] – hFLNA repeat 21+CFTR peptide – human<br />

[[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD<br />

[[3hoc]] – hFLNA ABD (mutant)<br />