1wbe

From Proteopedia

Revision as of 10:08, 30 October 2007

X-RAY STRUCTURE OF BOVINE GLTP

Overview

Glycolipids participate in many important cellular processes and they are, bound and transferred with high specificity by glycolipid transfer protein, (GLTP). We have solved three different X-ray structures of bovine GLTP at, 1.4 angstroms, 1.6 angstroms and 1.8 angstroms resolution, all with a, bound fatty acid or glycolipid. The 1.4 angstroms structure resembles the, recently characterized apo-form of the human GLTP but the other two, structures represent an intermediate conformation of the apo-GLTPs and the, human lactosylceramide-bound GLTP structure. These novel structures give, insight into the mechanism of lipid binding and how GLTP may, conformationally adapt to different lipids. Furthermore, based on the, structural comparison of the GLTP structures and the three-dimensional, ... [(full description)]

About this Structure

1WBE is a [Single protein] structure of sequence from [Bos taurus] with DKA and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structural evidence for adaptive ligand binding of glycolipid transfer protein., Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA, J Mol Biol. 2006 Jan 13;355(2):224-36. Epub 2005 Nov 8. PMID:16309699

Page seeded by OCA on Tue Oct 30 12:13:17 2007