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Group:MUZIC:ZASP
From Proteopedia
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=='''Introduction'''== | =='''Introduction'''== | ||
| - | <Structure load='1rgw' size='300' frame='true' align='right' caption='NMR solution structure of the PDZ domain of ZASP (PDB code: 1RGW)[http://www.rcsb.org/pdb/explore/explore.do?structureId=1RGW]' scene='User:Adekunle_Onipe/workbench/ZASP/Zasp_pdz_domain/3' /> | ||
ZASP is a component protein of the striated muscle Z-disk and a member of the [[enigma family]] of proteins. Like most enigma family members, it possess an N-terminal PDZ domain and three C-terminal LIM domains. The structure of the N-terminal PDZ domain has been solved (PDB ID: 1RGW) The PDZ domain has recently been characterized to bind a very C-terminal class III motif in myotilin [http://proteopedia.org/wiki/index.php/User:Denisa_Mullerova/workbench/Myotilin] and [[myozenin]], two other Z-disk members prominent during [[myofibrillogenesis]] and sarcomerogenesis [[http://proteopedia.org/wiki/index.php/User:Adekunle_Onipe/workbench/Sarcomerogenesis]]. | ZASP is a component protein of the striated muscle Z-disk and a member of the [[enigma family]] of proteins. Like most enigma family members, it possess an N-terminal PDZ domain and three C-terminal LIM domains. The structure of the N-terminal PDZ domain has been solved (PDB ID: 1RGW) The PDZ domain has recently been characterized to bind a very C-terminal class III motif in myotilin [http://proteopedia.org/wiki/index.php/User:Denisa_Mullerova/workbench/Myotilin] and [[myozenin]], two other Z-disk members prominent during [[myofibrillogenesis]] and sarcomerogenesis [[http://proteopedia.org/wiki/index.php/User:Adekunle_Onipe/workbench/Sarcomerogenesis]]. | ||
doi: 10.1083/jcb.146.2.465 | doi: 10.1083/jcb.146.2.465 | ||
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=='''Structure'''== | =='''Structure'''== | ||
| + | <Structure load='1rgw' size='250' frame='true' align='left' caption='NMR solution structure of the PDZ domain of ZASP (PDB code: 1RGW)[http://www.rcsb.org/pdb/explore/explore.do?structureId=1RGW]' scene='User:Adekunle_Onipe/workbench/ZASP/Zasp_pdz_domain/3' /> | ||
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| - | ZASP PDZ domain binds....... | ||
=='''Function and Interactions'''== | =='''Function and Interactions'''== | ||
Mutations within the c-terminal of ZASP has been identified.... | Mutations within the c-terminal of ZASP has been identified.... | ||
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=='''Pathology'''== | =='''Pathology'''== | ||
Revision as of 16:12, 7 July 2011
Contents |
Introduction
ZASP is a component protein of the striated muscle Z-disk and a member of the enigma family of proteins. Like most enigma family members, it possess an N-terminal PDZ domain and three C-terminal LIM domains. The structure of the N-terminal PDZ domain has been solved (PDB ID: 1RGW) The PDZ domain has recently been characterized to bind a very C-terminal class III motif in myotilin [1] and myozenin, two other Z-disk members prominent during myofibrillogenesis and sarcomerogenesis [[2]]. doi: 10.1083/jcb.146.2.465 http://jcb.rupress.org/content/146/2/465.full
Sequence annotation and domain topology
Canonical PDZ domains are known to target proteins to sites of complex formation, as such ZASP has been suggested as the oracle of Z-disk multi-protein complexes. This is also supported by the fact that the PDZ domain interacts with alpha-actinin-2, myotiin, myozenin.... Image:ZASP.png
Structure
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Function and Interactions
Mutations within the c-terminal of ZASP has been identified....
Pathology
References
Proteopedia Page Contributors and Editors (what is this?)
Adekunle Onipe, Nikos Pinotsis, Michal Harel, Jaime Prilusky
