Group:MUZIC:XIN
From Proteopedia
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| - | '''Xin actin-binding repeat-containing protein 1''' (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. | + | '''Xin actin-binding repeat-containing protein 1''' (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. Intraexogic splicing leads to a least three different isoforms. |
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<ref>PMID:19773341</ref> | <ref>PMID:19773341</ref> | ||
| - | == Interactions with other proteins/Function == | + | == Interactions with other proteins/Function Function == |
Xin and Mena/VASP colocalize with filamin c in [intercalated discs][http://en.wikipedia.org/wiki/Intercalated_disc](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart. | Xin and Mena/VASP colocalize with filamin c in [intercalated discs][http://en.wikipedia.org/wiki/Intercalated_disc](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart. | ||
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== Clinical significance == | == Clinical significance == | ||
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Revision as of 10:34, 10 July 2011
Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. Intraexogic splicing leads to a least three different isoforms.
Sequence Annotation
Function
Interactions with other proteins/Function Function
Xin and Mena/VASP colocalize with filamin c in [intercalated discs][1](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart.
Xin directly binds the EVH1 domain proteins Mena and VASP [2]
