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Group:MUZIC:XIN
From Proteopedia
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| - | == Interactions with other proteins/ | + | == Interactions with other proteins/ Function == |
Xin and Mena/VASP colocalize with filamin c in [intercalated discs][http://en.wikipedia.org/wiki/Intercalated_disc](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart <ref>PMID:19773341</ref>. | Xin and Mena/VASP colocalize with filamin c in [intercalated discs][http://en.wikipedia.org/wiki/Intercalated_disc](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart <ref>PMID:19773341</ref>. | ||
| - | Xin directly binds the EVH1 domain proteins Mena and VASP <ref name="pmid16631741">. | + | Xin directly binds the EVH1 domain proteins Mena and VASP <ref name="pmid16631741">.hkjjjjjjjjjjjjjjjjjjjjjj |
Xin binds the unique insertion of filamin c containing Ig domain 20. | Xin binds the unique insertion of filamin c containing Ig domain 20. | ||
Xin directly binds F-actin <ref name="pmid15454575">. | Xin directly binds F-actin <ref name="pmid15454575">. | ||
Revision as of 00:02, 12 July 2011
Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. Intraexogic splicing leads to a least three different isoforms.
Sequence Annotation
Interactions with other proteins/ Function
Xin and Mena/VASP colocalize with filamin c in [intercalated discs][1](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart [1].
Xin directly binds the EVH1 domain proteins Mena and VASP [2]
