1bhs
From Proteopedia
(New page: 200px<br /> <applet load="1bhs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bhs, resolution 2.20Å" /> '''HUMAN ESTROGENIC 17...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BHS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BHS OCA]]. | + | 1BHS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BHS OCA]]. |
==Reference== | ==Reference== | ||
Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution., Ghosh D, Pletnev VZ, Zhu DW, Wawrzak Z, Duax WL, Pangborn W, Labrie F, Lin SX, Structure. 1995 May 15;3(5):503-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7663947 7663947] | Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution., Ghosh D, Pletnev VZ, Zhu DW, Wawrzak Z, Duax WL, Pangborn W, Labrie F, Lin SX, Structure. 1995 May 15;3(5):503-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7663947 7663947] | ||
| + | [[Category: Estradiol 17-beta-dehydrogenase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: steroid dehydrogenase]] | [[Category: steroid dehydrogenase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:22:23 2007'' |
Revision as of 10:17, 30 October 2007
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HUMAN ESTROGENIC 17BETA-HYDROXYSTEROID DEHYDROGENASE
Overview
BACKGROUND: The principal human estrogen, 17 beta-estradiol, is a potent, stimulator of certain endocrine-dependent forms of breast cancer. Because, human estrogenic 17 beta-hydroxysteroid dehydrogenase (type I 17 beta-HSD), catalyzes the last step in the biosynthesis of 17 beta-estradiol from the, less potent estrogen, estrone, it is an attractive target for the design, of inhibitors of estrogen production and tumor growth. This human enzyme, shares less than 15% sequence identity with a bacterial 3 alpha,20, beta-HSD, for which the three-dimensional structure is known. The amino, acid sequence of 17 beta-HSD also differs from that of bacterial 3, alpha,20 beta-HSD by two insertions (of 11 and 14 residues) and 52, additional residues at the C terminus. RESULTS: The 2.20 A resolution, ... [(full description)]
About this Structure
1BHS is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Estradiol 17-beta-dehydrogenase], with EC number [1.1.1.62]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution., Ghosh D, Pletnev VZ, Zhu DW, Wawrzak Z, Duax WL, Pangborn W, Labrie F, Lin SX, Structure. 1995 May 15;3(5):503-13. PMID:7663947
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