2bfc
From Proteopedia
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m (Protected "2bfc" [edit=sysop:move=sysop]) |
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:016472748</ref><ref group="xtra">PMID:015166214</ref><ref group="xtra">PMID:012902323</ref><ref group="xtra">PMID:011069910</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Brautigam, C A.]] | [[Category: Brautigam, C A.]] | ||
| Line 30: | Line 30: | ||
[[Category: Tomchick, D R.]] | [[Category: Tomchick, D R.]] | ||
[[Category: Wynn, R M.]] | [[Category: Wynn, R M.]] | ||
| - | [[Category: Acylation]] | ||
| - | [[Category: Branched-chain]] | ||
[[Category: Conformational switch]] | [[Category: Conformational switch]] | ||
| - | [[Category: Ketoacid dehydrogenase]] | ||
[[Category: Maple syrup urine disease]] | [[Category: Maple syrup urine disease]] | ||
| - | [[Category: Multi- enzyme complex]] | ||
[[Category: Oxidative decarboxylation]] | [[Category: Oxidative decarboxylation]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
| - | [[Category: Reactivity]] | ||
[[Category: Thiamine diphosphate]] | [[Category: Thiamine diphosphate]] | ||
Revision as of 06:21, 24 August 2011
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Template:ABSTRACT PUBMED 16472748
About this Structure
2bfc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Machius M, Wynn RM, Chuang JL, Li J, Kluger R, Yu D, Tomchick DR, Brautigam CA, Chuang DT. A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase. Structure. 2006 Feb;14(2):287-98. PMID:16472748 doi:10.1016/j.str.2005.10.009
- Li J, Wynn RM, Machius M, Chuang JL, Karthikeyan S, Tomchick DR, Chuang DT. Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase. J Biol Chem. 2004 Jul 30;279(31):32968-78. Epub 2004 May 27. PMID:15166214 doi:http://dx.doi.org/10.1074/jbc.M403611200
- Wynn RM, Machius M, Chuang JL, Li J, Tomchick DR, Chuang DT. Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site. J Biol Chem. 2003 Oct 31;278(44):43402-10. Epub 2003 Aug 5. PMID:12902323 doi:http://dx.doi.org/10.1074/jbc.M306204200
- Wynn RM, Ho R, Chuang JL, Chuang DT. Roles of active site and novel K+ ion-binding site residues in human mitochondrial branched-chain alpha-ketoacid decarboxylase/dehydrogenase. J Biol Chem. 2001 Feb 9;276(6):4168-74. Epub 2000 Nov 7. PMID:11069910 doi:10.1074/jbc.M008038200
