3r2f

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'''Unreleased structure'''
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[[Image:3r2f.jpg|left|200px]]
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The entry 3r2f is ON HOLD until Paper Publication
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{{STRUCTURE_3r2f| PDB=3r2f | SCENE= }}
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Authors: Muckelbauer, J.K.
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===Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with BMS-693391 AKA (2S)-2-((3R)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-2-((2R,4R)-4-propoxy-2-pyrrolidinyl)ethyl)-4-phenylbutanamide===
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Description: Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with BMS-693391 AKA (2S)-2-((3R)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-2-((2R,4R)-4-propoxy-2-pyrrolidinyl)ethyl)-4-phenylbutanamide
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{{ABSTRACT_PUBMED_21782431}}
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==About this Structure==
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[[3r2f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R2F OCA].
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==Reference==
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<ref group="xtra">PMID:021782431</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Muckelbauer, J K.]]
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[[Category: Alzheimer's disease]]
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[[Category: Aspartic protease]]
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[[Category: Beta-secretase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Memapsin 2]]

Revision as of 06:47, 31 August 2011

Image:3r2f.jpg

Template:STRUCTURE 3r2f

Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with BMS-693391 AKA (2S)-2-((3R)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-2-((2R,4R)-4-propoxy-2-pyrrolidinyl)ethyl)-4-phenylbutanamide

Template:ABSTRACT PUBMED 21782431

About this Structure

3r2f is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Boy KM, Guernon JM, Shi J, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Marcinkeviciene J, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Lentz KA, Bronson JJ, Olson RE, Macor JE, Thompson LA 3rd. Monosubstituted gamma-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of beta-secretase (BACE). Bioorg Med Chem Lett. 2011 Jun 30. PMID:21782431 doi:10.1016/j.bmcl.2011.06.109

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OCA

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