1boy
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1boy.gif|left|200px]]<br /><applet load="1boy" size=" | + | [[Image:1boy.gif|left|200px]]<br /><applet load="1boy" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1boy, resolution 2.2Å" /> | caption="1boy, resolution 2.2Å" /> | ||
'''EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR'''<br /> | '''EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR'''<br /> | ||
| Line 10: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1BOY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Known structural/functional Sites: <scene name='pdbsite=7A1:Core Binding Site For Factor Viia Forming Concavity Betw ...'>7A1</scene>, <scene name='pdbsite=7A2:Distal Part Of Binding Site For Factor Viia On Convex Su ...'>7A2</scene> and <scene name='pdbsite=XA1:Site Of Interaction w. Macromolecular Substrate Xa Which ...'>XA1</scene>. Full crystallographic information is available from [http:// | + | 1BOY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Known structural/functional Sites: <scene name='pdbsite=7A1:Core+Binding+Site+For+Factor+Viia+Forming+Concavity+Betw+...'>7A1</scene>, <scene name='pdbsite=7A2:Distal+Part+Of+Binding+Site+For+Factor+Viia+On+Convex+Su+...'>7A2</scene> and <scene name='pdbsite=XA1:Site+Of+Interaction+w.+Macromolecular+Substrate+Xa+Which+...'>XA1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BOY OCA]. |
==Reference== | ==Reference== | ||
| Line 25: | Line 25: | ||
[[Category: initiator of blood coagulation in vertebrates]] | [[Category: initiator of blood coagulation in vertebrates]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:33:33 2008'' |
Revision as of 07:33, 3 February 2008
|
EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR
Contents |
Overview
Tissue factor is a cell-surface glycoprotein receptor which initiates the, blood coagulation cascade after vessel injury by interacting with blood, clotting factor VII/VIIa and which is implicated in various pathological, processes. When bound to tissue factor, factor VII is readily converted to, the active protease factor VIIa by trace amounts of factors Xa, IXa or, VIIa. Human tissue factor consists of 263 residues, the first 219 of which, comprise the extracellular region. We have determined the crystal, structure of the extracellular region at a resolution of 2.2 A. Tissue, factor consists of two immunoglobulin-like domains associated through an, extensive, novel, interdomain interface region. The binding site for, factor VII lies at the interface region and involves residues from domain, 1 and an extended loop (binding 'finger') of domain 2. This is the first, reported structure of a representative of the class 2 cytokine receptor, family, which also includes interferon-alpha, interferon-gamma (refs 2, 3), and interleukin-10 (ref. 4) receptors.
Disease
Known disease associated with this structure: Esophageal squamous cell carcinoma OMIM:[606551]
About this Structure
1BOY is a Single protein structure of sequence from Homo sapiens. Known structural/functional Sites: , and . Full crystallographic information is available from OCA.
Reference
Crystal structure of the extracellular region of human tissue factor., Harlos K, Martin DM, O'Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tuddenham EG, Boys CW, Nature. 1994 Aug 25;370(6491):662-6. PMID:8065454
Page seeded by OCA on Sun Feb 3 09:33:33 2008
