This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1dyq
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1dyq.gif|left|200px]]<br /><applet load="1dyq" size=" | + | [[Image:1dyq.gif|left|200px]]<br /><applet load="1dyq" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dyq, resolution 1.50Å" /> | caption="1dyq, resolution 1.50Å" /> | ||
'''STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE'''<br /> | '''STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1DYQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with ZN and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=ZN1:Zn Binding Site The Zn Ion Is Bound To Residues HIS A 18 ...'>ZN1</scene>. Full crystallographic information is available from [http:// | + | 1DYQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=ZN1:Zn+Binding+Site+The+Zn+Ion+Is+Bound+To+Residues+HIS+A+18+...'>ZN1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DYQ OCA]. |
==Reference== | ==Reference== | ||
| Line 22: | Line 22: | ||
[[Category: vaccine]] | [[Category: vaccine]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:36:03 2008'' |
Revision as of 07:36, 3 February 2008
|
STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE
Overview
Staphylococcal enterotoxins (SEs) are superantigenic protein toxins, responsible for a number of life-threatening diseases. The X-ray structure, of a staphylococcal enterotoxin A (SEA) triple-mutant (L48R, D70R, and, Y92A) vaccine reveals a cascade of structural rearrangements located in, three loop regions essential for binding the alpha subunit of major, histocompatibility complex class II (MHC-II) molecules. A comparison of, hypothetical model complexes between SEA and the SEA triple mutant with, MHC-II HLA-DR1 clearly shows disruption of key ionic and hydrophobic, interactions necessary for forming the complex. Extensive dislocation of, the disulfide loop in particular interferes with MHC-IIalpha binding. The, triple-mutant structure provides new insights into the loss of, superantigenicity and toxicity of an engineered superantigen and provides, a basis for further design of enterotoxin vaccines.
About this Structure
1DYQ is a Single protein structure of sequence from Staphylococcus aureus with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIalpha., Krupka HI, Segelke BW, Ulrich RG, Ringhofer S, Knapp M, Rupp B, Protein Sci. 2002 Mar;11(3):642-51. PMID:11847286
Page seeded by OCA on Sun Feb 3 09:36:03 2008
