1glo
From Proteopedia
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| - | [[Image:1glo.jpg|left|200px]]<br /><applet load="1glo" size=" | + | [[Image:1glo.jpg|left|200px]]<br /><applet load="1glo" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1glo, resolution 2.20Å" /> | caption="1glo, resolution 2.20Å" /> | ||
'''CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S'''<br /> | '''CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GLO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] Known structural/functional Site: <scene name='pdbsite=CAT:Active Site Residues In Native Enzyme'>CAT</scene>. Full crystallographic information is available from [http:// | + | 1GLO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] Known structural/functional Site: <scene name='pdbsite=CAT:Active+Site+Residues+In+Native+Enzyme'>CAT</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: thiol proteas]] | [[Category: thiol proteas]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:40:53 2008'' |
Revision as of 07:40, 3 February 2008
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CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S
Overview
Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain, superfamily, plays a critical role in the generation of a major, histocompatibility complex (MHC) class II restricted T-cell response by, antigen-presenting cells. Therefore, selective inhibition of this enzyme, may be useful in modulating class II restricted T-cell responses in, immune-related disorders such as rheumatoid arthritis, multiple sclerosis, and extrinsic asthma. The three-dimensional structure at 2.2 A resolution, of the active-site Cys25-->Ser mutant presented here in an unliganded, state provides further insight useful for the design of selective enzyme, inhibitors.
About this Structure
1GLO is a Single protein structure of sequence from Homo sapiens. Active as Cathepsin S, with EC number 3.4.22.27 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of a Cys25-->Ser mutant of human cathepsin S., Turkenburg JP, Lamers MB, Brzozowski AM, Wright LM, Hubbard RE, Sturt SL, Williams DH, Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):451-5. Epub 2002, Feb 21. PMID:11856830
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