1gue
From Proteopedia
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| - | [[Image:1gue.gif|left|200px]]<br /><applet load="1gue" size=" | + | [[Image:1gue.gif|left|200px]]<br /><applet load="1gue" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gue, resolution 2.27Å" /> | caption="1gue, resolution 2.27Å" /> | ||
'''SENSORY RHODOPSIN II'''<br /> | '''SENSORY RHODOPSIN II'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GUE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Natronomonas_pharaonis Natronomonas pharaonis] with CL and RET as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=RET:Cl Binding Site For Chain A'>RET</scene>. Full crystallographic information is available from [http:// | + | 1GUE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Natronomonas_pharaonis Natronomonas pharaonis] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=RET:'>RET</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=RET:Cl+Binding+Site+For+Chain+A'>RET</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUE OCA]. |
==Reference== | ==Reference== | ||
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[[Category: phototaxis]] | [[Category: phototaxis]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:42:44 2008'' |
Revision as of 07:42, 3 February 2008
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SENSORY RHODOPSIN II
Overview
Sensory rhodopsins are the primary receptors of vision in animals and, phototaxis in microorganisms. Light triggers the rapid isomerization of a, buried retinal chromophore, which the protein both accommodates and, amplifies into the larger structural rearrangements required for, signaling. We trapped an early intermediate of the photocycle of sensory, rhodopsin II from Natronobacterium pharaonis (pSRII) in 3D crystals and, determined its X-ray structure to 2.3 A resolution. The observed, structural rearrangements were localized near the retinal chromophore, with a key water molecule becoming disordered and the retinal's, beta-ionone ring undergoing a prominent movement. Comparison with the, early structural rearrangements of bacteriorhodopsin illustrates how, modifications in the retinal binding pocket of pSRII allow subtle, differences in the early relaxation of photoisomerized retinal.
About this Structure
1GUE is a Single protein structure of sequence from Natronomonas pharaonis with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Early structural rearrangements in the photocycle of an integral membrane sensory receptor., Edman K, Royant A, Nollert P, Maxwell CA, Pebay-Peyroula E, Navarro J, Neutze R, Landau EM, Structure. 2002 Apr;10(4):473-82. PMID:11937052
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