1h3m
From Proteopedia
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| - | [[Image:1h3m.jpg|left|200px]]<br /><applet load="1h3m" size=" | + | [[Image:1h3m.jpg|left|200px]]<br /><applet load="1h3m" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1h3m, resolution 2.40Å" /> | caption="1h3m, resolution 2.40Å" /> | ||
'''STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHETASE'''<br /> | '''STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHETASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1H3M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with CL and N2P as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] Known structural/functional Site: <scene name='pdbsite=AC1:N2p Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1H3M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=N2P:'>N2P</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] Known structural/functional Site: <scene name='pdbsite=AC1:N2p+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3M OCA]. |
==Reference== | ==Reference== | ||
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[[Category: synthetase]] | [[Category: synthetase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:45:54 2008'' |
Revision as of 07:45, 3 February 2008
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STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHETASE
Overview
2-C-Methyl-D-erythritol 4-phosphate cytidylyltransferase is an essential, enzyme in the mevalonate-independent pathway of isoprenoid biosynthesis., The structure of a tetragonal crystal form has been solved by molecular, replacement and refined to 2.4 A resolution. Structure and sequence, comparisons suggest that the enzyme is a suitable target for a, structure-based approach to the development of novel broad-spectrum, antibiotics. However, the absence of ligands in the enzyme active site, together with the moderate resolution of the structure indicates that this, tetragonal crystal form is inferior to that of a previously reported, highly ordered monoclinic form [Richard et al. (2001), Nature Struct., Biol. 8, 641-647].
About this Structure
1H3M is a Single protein structure of sequence from Escherichia coli with and as ligands. Active as 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, with EC number 2.7.7.60 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase., Kemp LE, Bond CS, Hunter WN, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):607-10. Epub 2003, Feb 21. PMID:12595740
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